Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.39 |
| ▸ | HPGDS | O60760 | 2/20 | 0.39 |
| ▸ | TTK | P33981 | 3/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18318272 | 0.88 | HRH3 (0.43) | HRH3KCNH2PARP1ADRA1ATTK | |
| SCHEMBL18318830 | 0.84 | PARP1 (0.47) | HRH3KCNH2PARP1HPGDS | |
| SCHEMBL18322887 | 0.84 | HRH3 (0.43) | HRH3KCNH2ADRA1ATGFBR1ACVR1 | |
| SCHEMBL18318946 | 0.83 | PIK3CD (0.47) | PARP1 | |
| SCHEMBL18318859 | 0.82 | CA12 (0.44) | HRH3KCNH2ADRA1ATTKPDGFRB | |
| SCHEMBL30497909 | 0.82 | CA12 (0.44) | HRH3KCNH2ADRA1ATTKPDGFRB | |
| Hydrochloric Acid SCHEMBL28550768 | 0.81 | CA12 (0.43) | HRH3KCNH2ADRA1ATTKPDGFRB | |
| SCHEMBL18322967 | 0.81 | PDGFRB (0.52) | HRH3KCNH2ADRA1ASMN1; SMN2PDGFRB | |
| SCHEMBL22260864 | 0.79 | NAMPT (0.49) | HRH3KCNH2PARP1ADRA1ASMN1; SMN2 | |
| SCHEMBL18322875 | 0.76 | GSK3B (0.44) | HRH3KCNH2TGFBR1ACVR1TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3310441-A1 | 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES | Cephalon, Inc. (US) | 2018-04-25 | — | — | EP | disclosed |
| WO-2016205633-A1 | 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES | CEPHALON, INC. (US) | 2016-12-22 | — | — | WO | disclosed |