Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 7/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 7/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30497909 | 0.87 | CA12 (0.44) | PDGFRBPDGFRAHRH3KCNH2ADRA1A | |
| SCHEMBL18318859 | 0.87 | CA12 (0.44) | PDGFRBPDGFRAHRH3KCNH2ADRA1A | |
| Hydrochloric Acid SCHEMBL28550768 | 0.86 | CA12 (0.43) | PDGFRBPDGFRAHRH3KCNH2ADRA1A | |
| SCHEMBL18322902 | 0.85 | PDGFRB (0.47) | PDGFRBPDGFRAHRH3KCNH2ADRA1A | |
| SCHEMBL18318241 | 0.83 | PDGFRB (0.50) | PDGFRBPDGFRAHRH3ALDH1A1F2 | |
| SCHEMBL18319021 | 0.82 | PIK3CA (0.51) | PDGFRBPDGFRA | |
| SCHEMBL18322876 | 0.81 | PDGFRB (0.57) | PDGFRBPDGFRAHRH3KCNH2ALDH1A1 | |
| SCHEMBL18322887 | 0.81 | HRH3 (0.43) | PDGFRBPDGFRAHRH3KCNH2ADRA1A | |
| SCHEMBL18322948 | 0.81 | HRH3 (0.44) | PDGFRBPDGFRAHRH3KCNH2ADRA1A | |
| SCHEMBL18319002 | 0.80 | CHEK2 (0.56) | PDGFRBPDGFRAALDH1A1HPGDPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3310441-A1 | 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES | Cephalon, Inc. (US) | 2018-04-25 | — | — | EP | disclosed |
| WO-2016205633-A1 | 1, 4-SUBSTITUTED PIPERIDINE DERIVATIVES | CEPHALON, INC. (US) | 2016-12-22 | — | — | WO | disclosed |