Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 5/20 | 0.36 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | MITF | O75030 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 6/20 | 0.35 |
| ▸ | KLK1 | P06870 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | GPR6 | P46095 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA3 | P07451 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15907220 | 0.84 | MAP3K5 (0.43) | MAP3K5RAB9ANPC1MITFKMT2A | |
| SCHEMBL18323181 | 0.78 | ATR (0.37) | RAB9ANPC1KMT2AMEN1CA1 | |
| SCHEMBL18323142 | 0.74 | MAP3K5 (0.34) | MAP3K5 | |
| SCHEMBL18323129 | 0.70 | F10 (0.45) | MAP3K5RAB9ANPC1KMT2AMEN1 | |
| SCHEMBL18323128 | 0.69 | NPC1 (0.52) | RAB9ANPC1KMT2AMEN1F10 | |
| SCHEMBL15907231 | 0.68 | MAP3K5 (0.42) | MAP3K5RAB9ANPC1MITFKMT2A | |
| SCHEMBL30962826 | 0.68 | PDE4D (0.43) | MAP3K5KMT2A | |
| SCHEMBL18323130 | 0.67 | NPC1 (0.36) | MAP3K5RAB9ANPC1KMT2AMEN1 | |
| SCHEMBL31582882 | 0.66 | NNMT (0.45) | MAP3K5GAAHPGD | |
| SCHEMBL30509874 | 0.66 | NNMT (0.45) | MAP3K5GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9522910-B2 | Protein kinase inhibitors (variants), use thereof in treating oncological diseases and a pharmaceutical composition based thereon | Obshchestvo s ogranichennoy otvetstvennostyou “Fusion Pharma” (RU) | 2016-12-20 | — | — | US | disclosed |