Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 15/20 | 0.60 |
| ▸ | ABL2 | P42684 | 2/20 | 0.58 |
| ▸ | KIT | P10721 | 3/20 | 0.56 |
| ▸ | RET | P07949 | 3/20 | 0.56 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.56 |
| ▸ | BCR | P11274 | 2/20 | 0.56 |
| ▸ | GAK | O14976 | 1/20 | 0.56 |
| ▸ | MLNR | O43193 | 1/20 | 0.56 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.56 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.56 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.56 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.56 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | FYN | P06241 | 1/20 | 0.56 |
| ▸ | PGR | P06401 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15907275 | 0.94 | ABL1 (0.52) | ABL1ABL2KITRETDDR1 | |
| SCHEMBL18323153 | 0.86 | ABL1 (0.78) | ABL1ABL2KITRETDDR1 | |
| SCHEMBL18323232 | 0.85 | RET (0.54) | ABL1KITRETDDR1EGFR | |
| SCHEMBL15789516 | 0.84 | ABL1 (0.79) | ABL1ABL2KITRETDDR1 | |
| SCHEMBL18323135 | 0.84 | ABL1 (0.79) | ABL1ABL2KITRETDDR1 | |
| SCHEMBL18323212 | 0.83 | KIT (0.51) | ABL1KITRETDDR1FGFR1 | |
| SCHEMBL18323193 | 0.82 | ABL1 (0.58) | ABL1ABL2KITRETBCR | |
| SCHEMBL18323147 | 0.80 | KIT (0.66) | ABL1KITRETEGFRFGFR1 | |
| SCHEMBL15907261 | 0.80 | ABL1 (0.68) | ABL1ABL2KITRETDDR1 | |
| SCHEMBL18323174 | 0.80 | ABL1 (0.55) | ABL1KITRETDDR1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9522910-B2 | Protein kinase inhibitors (variants), use thereof in treating oncological diseases and a pharmaceutical composition based thereon | Obshchestvo s ogranichennoy otvetstvennostyou “Fusion Pharma” (RU) | 2016-12-20 | — | — | US | disclosed |
| US-9522910-B2 | Protein kinase inhibitors (variants), use thereof in treating oncological diseases and a pharmaceutical composition based thereon | Obshchestvo s ogranichennoy otvetstvennostyou “Fusion Pharma” (RU) | 2016-12-20 | — | — | US | disclosed |