Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 3/20 | 0.54 |
| ▸ | KIT | P10721 | 10/20 | 0.54 |
| ▸ | ABL1 | P00519 | 4/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | BRAF | P15056 | 1/20 | 0.49 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15907303 | 0.94 | KIT (0.46) | RETKITABL1EGFRBRAF | |
| SCHEMBL18323212 | 0.87 | KIT (0.51) | RETKITABL1DDR1FGFR1 | |
| SCHEMBL18323214 | 0.86 | RET (0.54) | RETKITABL1DDR1FGFR1 | |
| SCHEMBL18323136 | 0.85 | ABL1 (0.60) | RETKITABL1EGFRBRAF | |
| SCHEMBL18323230 | 0.84 | FGFR1 (0.64) | KITABL1FGFR1KDRSRC | |
| SCHEMBL18323193 | 0.82 | ABL1 (0.58) | RETKITABL1BRAFFGFR1 | |
| SCHEMBL15907313 | 0.81 | KIT (0.44) | RETKITABL1DDR1FGFR1 | |
| SCHEMBL18323147 | 0.80 | KIT (0.66) | RETKITABL1EGFRBRAF | |
| SCHEMBL15907320 | 0.80 | RET (0.46) | RETKITABL1DDR1FGFR1 | |
| SCHEMBL15907275 | 0.78 | ABL1 (0.52) | RETKITABL1EGFRBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9522910-B2 | Protein kinase inhibitors (variants), use thereof in treating oncological diseases and a pharmaceutical composition based thereon | Obshchestvo s ogranichennoy otvetstvennostyou “Fusion Pharma” (RU) | 2016-12-20 | — | — | US | disclosed |
| US-9522910-B2 | Protein kinase inhibitors (variants), use thereof in treating oncological diseases and a pharmaceutical composition based thereon | Obshchestvo s ogranichennoy otvetstvennostyou “Fusion Pharma” (RU) | 2016-12-20 | — | — | US | disclosed |