Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 9/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.39 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1833103 | 0.86 | GSK3B (0.45) | GSK3B | |
| SCHEMBL2066266 | 0.83 | TACR1 (0.43) | GSK3BGAAKMT2AROCK1 | |
| Hydrochloric Acid SCHEMBL2064596 | 0.82 | GSK3B (0.42) | GSK3BGAAKMT2AROCK1 | |
| SCHEMBL4001200 | 0.77 | MAOB (0.54) | GSK3BHRH3 | |
| SCHEMBL1833070 | 0.77 | GSK3B (0.47) | GSK3B | |
| SCHEMBL4005923 | 0.76 | MAOB (0.49) | GSK3B | |
| SCHEMBL1832332 | 0.76 | GSK3B (0.47) | GSK3BHRH3PRKACAROCK1 | |
| SCHEMBL4870951 | 0.75 | GSK3B (0.47) | GSK3BHRH3 | |
| SCHEMBL2065326 | 0.75 | KMT2A (0.46) | GSK3BLMNAKMT2A | |
| SCHEMBL4001003 | 0.75 | ADORA2A (0.55) | GSK3BGAAKMT2AROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2321315-A2 | SUBSTITUTED ALKYL PYRIMIDIN-4-ONE DERIVATIVES | Mitsubishi Tanabe Pharma Corporation (JP) | 2011-05-18 | — | — | EP | disclosed |
| WO-2009156864-A2 | SUBSTITUTED ALKYL PYRIMIDIN-4-ONE DERIVATIVES | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2009-12-30 | — | — | WO | disclosed |