Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD1 | P17405 | 3/20 | 0.32 |
| ▸ | LAP3 | P28838 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | PGK1 | P00558 | 1/20 | 0.31 |
| ▸ | PGK2 | P07205 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | MMP1 | P03956 | 1/20 | 0.30 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | MMP9 | P14780 | 1/20 | 0.30 |
| ▸ | MMP8 | P22894 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
| ▸ | PEPD | P12955 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1832826 | 0.83 | SMPD1 (0.33) | SMPD1TDP1CA12CA1CA2 | |
| SCHEMBL26261582 | 0.79 | CTSA (0.32) | SMPD1KDM4ETDP1 | |
| SCHEMBL10447789 | 0.79 | SMPD1 (0.39) | SMPD1LAP3TDP1CA12CA1 | |
| SCHEMBL18239656 | 0.77 | CTSA (0.36) | KDM4ETDP1 | |
| SCHEMBL28604583 | 0.76 | SMPD1 (0.38) | SMPD1LAP3TDP1CA12CA1 | |
| SCHEMBL28622628 | 0.76 | SMPD1 (0.38) | SMPD1LAP3TDP1CA12CA1 | |
| SCHEMBL4367765 | 0.76 | TSHR (0.40) | MMP1MMP2MMP9 | |
| SCHEMBL17323854 | 0.76 | PRKCA (0.36) | — | |
| SCHEMBL28603594 | 0.76 | SMPD1 (0.37) | SMPD1LAP3MMP1MMP2 | |
| SCHEMBL137325 | 0.74 | TSHR (0.39) | PEPD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2320908-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2011-05-18 | — | — | EP | claimed |
| WO-2010011812-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2010-01-28 | — | — | WO | claimed |
| EP-2320909-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010011814-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2010-01-28 | — | — | WO | disclosed |