Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 3/20 | 0.48 |
| ▸ | GSR | P00390 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.40 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | HRH1 | P35367 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12530561 | 1.00 | TRPA1 (0.48) | TRPA1GSRSLC6A4SLC6A2TSHR | |
| SCHEMBL19511956 | 0.88 | GSR (0.43) | TRPA1GSRSLC6A4SLC6A2TSHR | |
| SCHEMBL18982890 | 0.83 | TRPA1 (0.47) | TRPA1GSRSLC6A4SLC6A2LMNA | |
| SCHEMBL872713 | 0.83 | GSR (0.53) | TRPA1GSRSLC6A4SLC6A2TSHR | |
| SCHEMBL2482267 | 0.83 | GSR (0.53) | TRPA1GSRSLC6A4SLC6A2TSHR | |
| SCHEMBL2064318 | 0.83 | GSR (0.53) | TRPA1GSRSLC6A4SLC6A2TSHR | |
| SCHEMBL10755600 | 0.82 | TRPA1 (0.43) | TRPA1GSRSLC6A4SLC6A2TSHR | |
| SCHEMBL21280877 | 0.81 | TRPA1 (0.43) | TRPA1GSRSLC6A4SLC6A2TSHR | |
| SCHEMBL14198942 | 0.81 | TRPA1 (0.50) | TRPA1GSRSLC6A4SLC6A2TSHR | |
| SCHEMBL1098807 | 0.81 | AOC3 (0.43) | SLC6A4SLC6A2TSHRCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107406744-A | ADHESIVE COMPOSITION AND LAMINATE | 东洋油墨SC控股株式会社 | 2017-11-28 | — | — | CN | disclosed |
| EP-2321287-B1 | 4,5-DIHYDRO-OXAZOL-2-YL DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2015-11-11 | — | — | EP | disclosed |
| US-8729113-B2 | 4,5-dihydro-oxazol-2yl derivatives | HOFFMANN-LA ROCHE INC. (US) | 2014-05-20 | — | — | US | disclosed |
| US-8357712-B2 | — | — | 2013-01-22 | — | — | US | disclosed |
| CN-101659694-B | Anti-tumor cyclic pentapeptide compound and preparation method thereof | UNIV HEBEI SCIENCE & TECH | 2012-12-12 | — | — | CN | disclosed |
| CN-102816257-A | Preparation method of methoxylphenyl propanol substituted 6-amino-beta-cyclodextrin derivative | SHANGHAI RUICHUANG MEDICAL TECHNOLOGY CO LTD | 2012-12-12 | — | — | CN | disclosed |
| CN-102816257-A | Preparation method of methoxylphenyl propanol substituted 6-amino-beta-cyclodextrin derivative | SHANGHAI RUICHUANG MEDICAL TECHNOLOGY CO LTD | 2012-12-12 | — | — | CN | disclosed |
| US-8242153-B2 | 4,5-dihydro-oxazol-2YL derivatives | HOFFMANN-LA ROCHE INC. (US) | 2012-08-14 | — | — | US | disclosed |
| US-20120165294-A1 | 4,5-DIHYDRO-OXAZOL-2YL DERIVATIVES | GALLEY GUIDO (DE) | 2012-06-28 | — | — | US | disclosed |
| US-20110144333-A1 | 4,5-DIHYDRO-OXAZOL-2YL DERIVATIVES | GALLEY GUIDO | 2011-06-16 | — | — | US | disclosed |
| EP-2321287-A1 | 4,5-DIHYDRO-OXAZOL-2-YL DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2011-05-18 | — | — | EP | disclosed |
| CN-101659694-A | Anti-tumor cyclic pentapeptide compound and preparation method thereof | UNIV HEBEI SCIENCE & TECH | 2010-03-03 | — | — | CN | disclosed |
| US-20100041686-A1 | 4,5-DIHYDRO-OXAZOL-2YL DERIVATIVES | HOFFMANN-LA ROCHE, INC. | 2010-02-18 | — | — | US | disclosed |
| US-20100029589-A1 | 4,5-DIHYDRO-OXAZOL-2YL DERIVATIVES | HOFFMANN-LA ROCHE INC. | 2010-02-04 | — | — | US | disclosed |
| WO-2010010014-A1 | 4,5-DIHYDRO-OXAZOL-2-YL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-01-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144333-A1 | 4,5-DIHYDRO-OXAZOL-2YL DERIVATIVES | NPY5R, NPY1R, NPY4R | TRPA1 272/4885GSR 1388/4885SLC6A4 65/4885 |
| US-20100029589-A1 | 4,5-DIHYDRO-OXAZOL-2YL DERIVATIVES | NPY5R, NPY1R, NPY4R | TRPA1 272/4885GSR 1388/4885SLC6A4 65/4885 |
| US-20100041686-A1 | 4,5-DIHYDRO-OXAZOL-2YL DERIVATIVES | NPY5R, NPY1R, NPY4R | TRPA1 272/4885GSR 1388/4885SLC6A4 65/4885 |
| US-20120165294-A1 | 4,5-DIHYDRO-OXAZOL-2YL DERIVATIVES | NPY5R, NPY1R, NPY4R | TRPA1 272/4885GSR 1388/4885SLC6A4 65/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.