Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.55 |
| ▸ | TP53 | P04637 | 12/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL388772 | 0.88 | GPR119 (0.57) | GPR119TP53LMNAALDH1A1HSD17B10 | |
| SCHEMBL389381 | 0.81 | GPR119 (0.59) | GPR119TP53LMNAALDH1A1HSD17B10 | |
| SCHEMBL388470 | 0.81 | GPR119 (0.58) | GPR119TP53LMNAALDH1A1HSD17B10 | |
| SCHEMBL390957 | 0.80 | GPR119 (0.82) | GPR119TP53LMNAALDH1A1HSD17B10 | |
| SCHEMBL389222 | 0.79 | GPR119 (0.58) | GPR119TP53LMNAALDH1A1HSD17B10 | |
| SCHEMBL1833273 | 0.79 | TP53 (0.50) | GPR119TP53LMNAALDH1A1HSD17B10 | |
| SCHEMBL389412 | 0.78 | GPR119 (0.58) | GPR119TP53LMNAALDH1A1HSD17B10 | |
| SCHEMBL12914919 | 0.77 | TP53 (0.74) | GPR119TP53LMNAALDH1A1HSD17B10 | |
| SCHEMBL391160 | 0.75 | GPR119 (0.91) | GPR119ALDH1A1HSD17B10NPC1HPGD | |
| SCHEMBL1244863 | 0.74 | GPR119 (0.60) | GPR119TP53LMNAALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2322150-A2 | Method of identifying GLP-1 secretagogues | Arena Pharmaceuticals, Inc. (US) | 2011-05-18 | — | — | EP | disclosed |
| EP-2322157-A1 | Composition for the treatment of diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood GLP-1 level | Arena Pharmaceuticals, Inc. (US) | 2011-05-18 | — | — | EP | disclosed |
| EP-2322151-A2 | Sustained release formulation comprising a GPR119 agonist and a DPP-IV inhibitor | Arena Pharmaceuticals, Inc. (US) | 2011-05-18 | — | — | EP | disclosed |