Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUCY1A1 | Q02108 | 19/20 | 0.45 |
| ▸ | GUCY1B1 | Q02153 | 19/20 | 0.45 |
| ▸ | GUCY1B2 | O75343 | 2/20 | 0.36 |
| ▸ | GUCY1A2 | P33402 | 2/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1780851 | 0.90 | GUCY1A1 (0.56) | GUCY1A1GUCY1B1KEAP1NFE2L2 | |
| SCHEMBL18335005 | 0.90 | GUCY1A1 (0.46) | GUCY1A1GUCY1B1GUCY1B2GUCY1A2 | |
| SCHEMBL18335039 | 0.89 | GUCY1A1 (0.45) | GUCY1A1GUCY1B1 | |
| SCHEMBL18335015 | 0.89 | GUCY1A1 (0.45) | GUCY1A1GUCY1B1 | |
| SCHEMBL18044301 | 0.88 | GUCY1A1 (0.53) | GUCY1A1GUCY1B1 | |
| SCHEMBL18335023 | 0.87 | GUCY1A1 (0.41) | GUCY1A1GUCY1B1GUCY1B2GUCY1A2KEAP1 | |
| SCHEMBL18335033 | 0.87 | GUCY1A1 (0.41) | GUCY1A1GUCY1B1GUCY1B2GUCY1A2KEAP1 | |
| SCHEMBL1781270 | 0.86 | GUCY1A1 (0.56) | GUCY1A1GUCY1B1 | |
| SCHEMBL18334997 | 0.85 | GUCY1A1 (0.41) | GUCY1A1GUCY1B1KEAP1NFE2L2 | |
| SCHEMBL18335041 | 0.83 | RXRA (0.40) | GUCY1A1GUCY1B1KEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2197551-B1 | SOLUBLE GUANYLATE CYCLASE ACTIVATORS | MERCK SHARP & DOHME (US) | 2016-12-28 | — | — | EP | claimed |