Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Lactic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cadaverine Tartrate SCHEMBL1830016 | 0.87 | TSHR (0.43) | KDM4EMEN1KMT2AALDH1A1HPGD | |
| Cadaverine Tartrate SCHEMBL1830017 | 0.87 | TSHR (0.43) | KDM4EMEN1KMT2AALDH1A1HPGD | |
| Lactic Acid SCHEMBL28158391 | 0.84 | TP53 (0.61) | TP53MEN1KMT2AALDH1A1TSHR | |
| Bicarbonate SCHEMBL1831706 | 0.84 | KDM4E (0.46) | KDM4EMEN1KMT2AALDH1A1HPGD | |
| Bicarbonate SCHEMBL1834592 | 0.84 | KDM4E (0.46) | KDM4EMEN1KMT2AALDH1A1HPGD | |
| Acetic Acid SCHEMBL358197 | 0.81 | KDM4E (0.45) | KDM4EMEN1KMT2AALDH1A1HPGD | |
| Oxalic Acid SCHEMBL1835271 | 0.81 | KDM4E (0.53) | KDM4EMEN1KMT2AALDH1A1TSHR | |
| Oxalic Acid SCHEMBL1835268 | 0.81 | KDM4E (0.53) | KDM4EMEN1KMT2AALDH1A1TSHR | |
| Malic Acid SCHEMBL1833281 | 0.80 | SMN1; SMN2 (0.56) | KDM4EMEN1KMT2AALDH1A1HPGD | |
| Malic Acid SCHEMBL1833279 | 0.80 | SMN1; SMN2 (0.56) | KDM4EMEN1KMT2AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070185330-A1 | Liquids | THE UNIVERSITY OF YORK (GB) | 2007-08-09 | — | — | US | claimed |
| US-9328220-B2 | Liquids | INNOVIA FILMS LIMITED (GB) | 2016-05-03 | — | — | US | disclosed |
| US-8992798-B2 | Liquids | INNOVIA FILMS LIMITED (GB) | 2015-03-31 | — | — | US | disclosed |
| US-8784686-B2 | Liquids | INNOVIA FILMS LIMITED (GB) | 2014-07-22 | — | — | US | disclosed |
| US-20140187684-A1 | LIQUIDS | INNOVIA FILMS LIMITED (GB) | 2014-07-03 | — | — | US | disclosed |
| US-20110257433-A1 | LIQUIDS | THE UNIVERSITY OF YORK (GB) | 2011-10-20 | — | — | US | disclosed |
| EP-2322497-A1 | Ionic liquids comprising nitrogen containing cations | Innovia Films Limited (GB) | 2011-05-18 | — | — | EP | disclosed |
| US-20080221361-A1 | Ionic Liquids | BIONIQS LIMITED (GB) | 2008-09-11 | — | — | US | disclosed |
| EP-1948589-A1 | IONIC LIQUIDS | Bioniqs Limited (GB) | 2008-07-30 | — | — | EP | disclosed |
| US-20070185330-A1 | Liquids | THE UNIVERSITY OF YORK (GB) | 2007-08-09 | — | — | US | disclosed |
| WO-2007036712-A1 | IONIC LIQUIDS | BIONIQS LIMITED (GB) | 2007-04-05 | — | — | WO | disclosed |