Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 15/20 | 0.38 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.38 |
| ▸ | TTK | P33981 | 5/20 | 0.36 |
| ▸ | ROS1 | P08922 | 4/20 | 0.36 |
| ▸ | GAK | O14976 | 3/20 | 0.36 |
| ▸ | INSR | P06213 | 3/20 | 0.36 |
| ▸ | IGF1R | P08069 | 3/20 | 0.36 |
| ▸ | LTK | P29376 | 3/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.36 |
| ▸ | TNK2 | Q07912 | 3/20 | 0.36 |
| ▸ | TNK1 | Q13470 | 3/20 | 0.36 |
| ▸ | PTK2B | Q14289 | 3/20 | 0.36 |
| ▸ | EGFR | P00533 | 3/20 | 0.36 |
| ▸ | INSRR | P14616 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | CLK1 | P49759 | 2/20 | 0.36 |
| ▸ | FES | P07332 | 3/20 | 0.36 |
| ▸ | FLT3 | P36888 | 3/20 | 0.36 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.36 |
| ▸ | PLK4 | O00444 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18338691 | 0.87 | ALK (0.39) | ALKZAP70TTKROS1GAK | |
| SCHEMBL22494176 | 0.77 | ALK (0.37) | ALKINSRIGF1REGFR | |
| SCHEMBL15207525 | 0.77 | ALK (0.37) | ALKROS1INSREGFRMET | |
| SCHEMBL21715308 | 0.73 | ALK (0.60) | ALKZAP70TTKROS1GAK | |
| SCHEMBL11900490 | 0.72 | ALK (0.63) | ALKZAP70TTKROS1GAK | |
| SCHEMBL11901912 | 0.69 | ALK (0.46) | ALKZAP70TTKROS1GAK | |
| SCHEMBL14857729 | 0.69 | ALK (0.61) | ALKZAP70TTKROS1GAK | |
| SCHEMBL1493628 | 0.67 | ALK (0.68) | ALKZAP70TTKROS1GAK | |
| SCHEMBL17527398 | 0.66 | ALK (0.54) | ALKZAP70TTKROS1GAK | |
| SCHEMBL11901307 | 0.64 | ALK (0.52) | ALKZAP70TTKROS1GAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160376297-A1 | Phosphorous Derivatives as Kinase Inhibitors | ARIAD PHARMA INC (US) | 2016-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160376297-A1 | Phosphorous Derivatives as Kinase Inhibitors | MAP3K6, PIK3CA, MAP3K20 | ALK 265/4885ZAP70 525/4885TTK 398/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.