Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 20/20 | 1.00 |
| ▸ | SIRT1 | Q96EB6 | 17/20 | 1.00 |
| ▸ | SIRT3 | Q9NTG7 | 17/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18339833 | 0.95 | SIRT2 (1.00) | SIRT2SIRT1SIRT3 | |
| SCHEMBL18340514 | 0.94 | SIRT2 (1.00) | SIRT2SIRT1SIRT3 | |
| SCHEMBL18339338 | 0.94 | SIRT2 (1.00) | SIRT2SIRT1SIRT3 | |
| SCHEMBL18340130 | 0.94 | SIRT2 (1.00) | SIRT2SIRT1SIRT3 | |
| SCHEMBL18340495 | 0.93 | SIRT2 (1.00) | SIRT2SIRT1SIRT3 | |
| SCHEMBL18339852 | 0.93 | SIRT2 (1.00) | SIRT2SIRT1SIRT3 | |
| SCHEMBL18340304 | 0.92 | SIRT2 (1.00) | SIRT2SIRT1SIRT3 | |
| SCHEMBL18339539 | 0.91 | SIRT2 (1.00) | SIRT2SIRT1SIRT3 | |
| SCHEMBL20078376 | 0.91 | SIRT2 (1.00) | SIRT2SIRT1SIRT3 | |
| SCHEMBL18339969 | 0.91 | SIRT2 (0.88) | SIRT2SIRT1SIRT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180194731-A1 | THERAPEUTIC COMPOUNDS | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2018-07-12 | — | — | US | disclosed |
| US-20180194731-A1 | THERAPEUTIC COMPOUNDS | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2018-07-12 | — | — | US | disclosed |
| US-20180194731-A1 | THERAPEUTIC COMPOUNDS | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2018-07-12 | — | — | US | disclosed |
| US-9951019-B2 | Therapeutic compounds | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2018-04-24 | — | — | US | disclosed |
| US-9951019-B2 | Therapeutic compounds | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2018-04-24 | — | — | US | disclosed |
| US-9951019-B2 | Therapeutic compounds | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2018-04-24 | — | — | US | disclosed |
| US-20160376238-A1 | THERAPEUTIC COMPOUNDS | REGENTS OF THE UNIVERSITY OF MINNESOTA | 2016-12-29 | — | — | US | disclosed |
| US-20160376238-A1 | THERAPEUTIC COMPOUNDS | REGENTS OF THE UNIVERSITY OF MINNESOTA | 2016-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160376238-A1 | THERAPEUTIC COMPOUNDS | SIRT2, SIRT1, SIRT3 | SIRT2 1/4885SIRT1 2/4885SIRT3 3/4885 |
| US-20180194731-A1 | THERAPEUTIC COMPOUNDS | SIRT2, SIRT1, SIRT3 | SIRT2 1/4885SIRT1 2/4885SIRT3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.