Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Monoethanolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | OR51E2 | Q9H255 | 2/20 | 0.47 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.47 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.47 |
| ▸ | GABRR1 | P24046 | 6/20 | 0.42 |
| ▸ | BLM | P54132 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.42 |
| ▸ | GABRR2 | P28476 | 3/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | GABRR3 | A8MPY1 | 2/20 | 0.42 |
| ▸ | GABRP | O00591 | 1/20 | 0.42 |
| ▸ | GABRD | O14764 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Monoethanolamine SCHEMBL1263481 | 1.00 | — | — | |
| Monoethanolamine SCHEMBL30732439 | 0.96 | — | — | |
| Monoethanolamine SCHEMBL15062838 | 0.96 | TSHR (0.61) | TSHRALDH1A1OR51E2GLRA1SLC6A9 | |
| Monoethanolamine SCHEMBL8492825 | 0.96 | — | — | |
| Monoethanolamine SCHEMBL20920088 | 0.96 | TSHR (0.61) | TSHRALDH1A1OR51E2GLRA1SLC6A9 | |
| Monoethanolamine SCHEMBL11844287 | 0.93 | TSHR (0.57) | TSHRALDH1A1OR51E2GLRA1SLC6A9 | |
| Monoethanolamine SCHEMBL4072780 | 0.89 | TSHR (0.53) | TSHRALDH1A1OR51E2GLRA1SLC6A9 | |
| Oxalic Acid SCHEMBL1837927 | 0.88 | TSHR (0.61) | TSHRALDH1A1OR51E2GLRA1SLC6A9 | |
| Carbamic Acid SCHEMBL8586267 | 0.88 | — | — | |
| Oxalic Acid SCHEMBL9489537 | 0.88 | TSHR (0.61) | TSHRALDH1A1OR51E2GLRA1SLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112029140-B | Polyurethane composite foaming agent containing dialkyl carbonate | 毕戈华 | 2023-08-11 | — | — | CN | claimed |
| CN-112029134-B | Polyurethane composite foaming agent containing dialkyl carbonate and alkanolamine salt | 毕戈华 | 2023-01-24 | — | — | CN | claimed |
| CN-109422906-B | Ethanolamine alkaline blowing agents and use for producing polyurethane solar foam materials | 山东理工大学 | 2021-03-19 | — | — | CN | claimed |
| CN-109422898-B | Blowing agents comprising tertiary amine salts and ethanolamine salts and use for polyurethane slabstock foam materials | 山东理工大学 | 2021-03-19 | — | — | CN | claimed |
| CN-109422905-B | Tertiary amine and ethanolamine alkaline blowing agents and use for producing polyurethane solar foam materials | 山东理工大学 | 2021-03-19 | — | — | CN | claimed |
| CN-109422897-B | Blowing agents comprising primary amine salts and ethanolamine salts and use for polyurethane slabstock foam materials | 山东理工大学 | 2021-03-12 | — | — | CN | claimed |
| CN-109422908-B | Blowing agents comprising polyamine and ethanolamine salts and use for polyurethane slabstock foam materials | 补天新材料技术有限公司 | 2021-03-12 | — | — | CN | claimed |
| CN-109422900-B | Secondary amine and ethanolamine alkaline blowing agents and use for producing polyurethane solar foam materials | 山东理工大学 | 2021-03-12 | — | — | CN | claimed |
| CN-109422916-B | Blowing agents comprising secondary amine salts and ethanolamine salts and use for polyurethane slabstock foam materials | 山东理工大学 | 2021-02-19 | — | — | CN | claimed |
| CN-109422914-B | Polyamine ethanolamine alkaline foaming agent and application for preparing polyurethane solar foam material | 补天新材料技术有限公司 | 2021-02-09 | — | — | CN | claimed |
| CN-109422915-B | Blowing agent comprising orthomethanolate and ethanolamine salts and use for polyurethane slabstock foam materials | 补天新材料技术有限公司 | 2021-02-09 | — | — | CN | claimed |
| CN-109422859-B | Ortho-methanolate and ethanolamine carbonate alkaline blowing agents and use for producing polyurethane solar foam materials | 补天新材料技术有限公司 | 2021-01-22 | — | — | CN | claimed |
| EP-3719064-A1 | ORGANIC AMINE SALT FOAMER | Shandong University Of Technology (CN) | 2020-10-07 | — | — | EP | claimed |
| US-20200291199-A1 | Organic Amine Salt Foamer | SHANDONG UNIVERSITY OF TECHNOLOGY (CN) | 2020-09-17 | — | — | US | claimed |
| WO-2019075875-A1 | ORGANIC AMINE SALT FOAMER | 山东理工大学 | 2019-04-25 | — | — | WO | claimed |
| EP-3466916-A1 | ORGANIC AMINE SALT COMPOUND HAVING ANIONS SERVING AS CO2 DONORS AND APPLICATION OF SAME AS FOAMING AGENT | Shandong University Of Technology (CN) | 2019-04-10 | — | — | EP | claimed |
| CN-118290924-A | Organic silicon foaming material and preparation method thereof | 万华化学集团股份有限公司 | 2024-07-05 | — | — | CN | disclosed |
| CN-114805908-B | Polyurethane composite foaming agent and application thereof | 芜湖美的智能厨电制造有限公司 | 2023-08-15 | — | — | CN | disclosed |
| EP-1140745-A1 | COLCHINOL DERIVATIVES AS VASCULAR DAMAGING AGENTS | Angiogene Pharmaceuticals Ltd (GB) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000040529-A1 | COLCHINOL DERIVATIVES AS VASCULAR DAMAGING AGENTS | ANGIOGENE PHARMACEUTICALS LTD. (GB) | 2000-07-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200291199-A1 | Organic Amine Salt Foamer | MSMO1, ALKBH3, ALKBH2 | TSHR 4275/4885ALDH1A1 1284/4885OR51E2 37/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.