ALKBH2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL2714869	0.54	9/20
SCHEMBL2877411	0.51	8/20
SCHEMBL2226023	0.49	8/20
SCHEMBL2716237	0.50	7/20
SCHEMBL4612998	0.49	7/20
SCHEMBL2225644	0.46	7/20
SCHEMBL2225645	0.46	7/20
SCHEMBL5215154	0.45	7/20
SCHEMBL6236560	0.50	6/20
SCHEMBL2871990	0.49	6/20
SCHEMBL6232231	0.47	6/20
SCHEMBL1920448	0.47	5/20
SCHEMBL2875276	0.39	5/20
SCHEMBL111587	0.42	4/20
SCHEMBL2272913	0.41	4/20
SCHEMBL72377	0.54	3/20
SCHEMBL2276257	0.53	3/20
Water (SCHEMBL2650345)	0.53	3/20
SCHEMBL5212649	0.47	3/20
SCHEMBL2713556	0.44	3/20

Clinical trials — most relevant to ALKBH2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Randomized Study of Decitabine in Maintenance Therapy of Acute Myeloid Leukemia (AML)	PHASE2/PHASE3	COMPLETED
Treatment With Azacitidine of Recurrent Gliomas With IDH1/2 Mutation	PHASE2	UNKNOWN
IDH1 (AG 120) Inhibitor in Patients With IDH1 Mutated Myelodysplastic Syndrome	PHASE2	ACTIVE_NOT_RECRUITING
A Multi-Histology Phase II Study of 5-Fluoro-2'-Deoxycytidine With Tetrahydrouridine (FdCyd + THU)	PHASE2	COMPLETED
Evaluating in Vivo AZA Incorporation in Mononuclear Cells Following Vidaza or CC486	PHASE2	COMPLETED
Decitabine/Cedazuridine (INQOVI), an Oral DNA Demethylating Agent, in Subjects With BAP1 Cancer Predisposition Syndrome and Subclinical, Early-Stage Mesothelioma	PHASE2	SUSPENDED
A Phase 1 Safety and Dose Finding Study of GLIX1 in Adults With Recurrent or Progressive High-grade Glioma	PHASE1	RECRUITING
Phase I Trial of 4'-Thio-2'-Deoxycytidine (TdCyd) in Patients With Advanced Solid Tumors	PHASE1	COMPLETED
5-aza-4'-Thio-2'-Deoxycytidine (Aza-TdC) in People With Advanced Solid Tumors	PHASE1	RECRUITING
A Study of Low-Dose Decitabine in Relapsed or Refractory Acute Lymphocytic Leukemia (ALL)	PHASE1	COMPLETED
Expression of TET1 Gene in Acute Leukaemia	nan	UNKNOWN
Epitranscriptomic Blood Biomarkers for Coronary Artery Disease - A Prospective Cohort Study (IHD-EPITRAN)	nan	UNKNOWN
The Molecular Pathogenesis Study of Cataract	nan	UNKNOWN
Efficacy of Essential Phospholipid Versus Betaine HCL/L-Glutamic Acid in MAFLD	nan	NOT_YET_RECRUITING
Hydroxymethylation, Incident Type 2 Diabetes and Incident Obesity	nan	UNKNOWN
Investigation of the Genetic and Environmental Causes of Autism: a Multi-Center Study	nan	NOT_YET_RECRUITING
Prognosis of METTL-14 in Endometrial Carcinoma	nan	NOT_YET_RECRUITING
Prevalence and Clinical Effect of IDH1/2 Mutations in Patients With Acute Myeloid Leukemia	nan	UNKNOWN
Impact Of Choline in Patients With NAFLD	nan	UNKNOWN
Atrial Appendage Micrograft Transplants to Assist Heart Repair After Cardiac Surgery	nan	RECRUITING
A Proof of Concept Study for the DNA Repair Driven by the Mesenchymal Stem Cells in Critical COVID-19 Patients	nan	COMPLETED
Residual Hypermethylation in Early Stage Non-Small Cell Lung Cancer (NSCLC) As Part of Adjuvant Therapy and Preventive Strategy	nan	COMPLETED
Effects of Contact Restrictions During the COVID-19 Pandemic on Newborns and Their Parents	nan	COMPLETED
Genetics and Epigenetics of Graves' Orbitopathy	nan	COMPLETED
Immune Responses With Reduxium	nan	COMPLETED
Impact of O6-methylguanine-DNA Methyltransferase (MGMT) Promoter Methylation and MGMT Expression on Dacarbazine Treated Sarcoma Patients (MGMT)	nan	UNKNOWN
Molecular Profiling for Risk Stratification in Appendiceal Cancer	nan	RECRUITING
Effects of High Altitude on AMPK Activation	nan	RECRUITING
DNA Repair Genes and Outcomes in Patients With Stage III NSCLC	nan	UNKNOWN
Adenosylmethionine Metabolism in Human Inflammation	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a ALKBH2 binder may also engage these)

Protein	Name	Similarity
Q58DM4	—	0.999	Q58DM4 →
Q6P6J4	—	0.995	Q6P6J4 →
Q8K1E6	—	0.992	Q8K1E6 →
ALKBH3	Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3	0.989	landscape →
Q32L00	—	0.984	Q32L00 →
D3ZEY4	—	0.981	D3ZEY4 →
KAT8	Histone acetyltransferase KAT8	0.981	landscape →
P28866	—	0.981	P28866 →
ALKBH1	Nucleic acid dioxygenase ALKBH1	0.980	landscape →
Q8WYJ6	—	0.980	Q8WYJ6 →
Q7XWV4	—	0.980	Q7XWV4 →
SMOX	Spermine oxidase	0.980	landscape →
Q2QMG2	—	0.980	Q2QMG2 →
Q8LI34	—	0.980	Q8LI34 →
Q5XI69	—	0.979	Q5XI69 →
P40694	—	0.979	P40694 →
F4IDQ6	—	0.979	F4IDQ6 →
Q5XI06	—	0.979	Q5XI06 →
A0A2K3D179	—	0.979	A0A2K3D179 →
Q6P5E8	—	0.979	Q6P5E8 →
KDM5B	Lysine-specific demethylase 5B	0.979	landscape →
Q5BJS0	—	0.979	Q5BJS0 →
Q767K6	—	0.979	Q767K6 →
P28855	—	0.978	P28855 →
O60231	—	0.978	O60231 →
DCPS	m7GpppX diphosphatase	0.978	landscape →
Q84WU9	—	0.978	Q84WU9 →
P06623	—	0.978	P06623 →
A1L251	—	0.978	A1L251 →
Q754C9	—	0.978	Q754C9 →