Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 8/20 | 0.49 |
| ▸ | NPC1 | O15118 | 6/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25598124 | 0.87 | RAB9A (0.57) | MAPTALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL2244923 | 0.86 | POLB (0.53) | MAPTALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL3356620 | 0.85 | RAB9A (0.50) | MAPTALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL20296299 | 0.84 | CNR2 (0.49) | MAPTALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL3754634 | 0.78 | RAB9A (0.48) | MAPTALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL13054087 | 0.78 | RAB9A (0.48) | MAPTALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL31349462 | 0.77 | NPC1 (0.53) | MAPTALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL18344059 | 0.77 | — | — | |
| SCHEMBL25258653 | 0.76 | RAB9A (0.52) | MAPTALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL25258655 | 0.76 | RAB9A (0.52) | MAPTALDH1A1RAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3310767-A1 | NADPH OXIDASE 4 INHIBITORS | Actelion Pharmaceuticals Ltd. (CH) | 2018-04-25 | — | — | EP | disclosed |
| WO-2016207785-A1 | NADPH OXIDASE 4 INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2016-12-29 | — | — | WO | disclosed |