SCHEMBL18351797

SCHEMBL18351797

COc1cccc(Cn2ccc3ccc(Nc4nc(N[C@@H]5CCCC[C@@H]5N)ncc4C(N)=O)cc32)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ SYK P43405 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18351796 1.00 SYK (1.00) SYK
SCHEMBL18351789 0.92 SYK (1.00) SYK
SCHEMBL18351787 0.92 SYK (1.00) SYK
SCHEMBL18351813 0.90 SYK (1.00) SYK
SCHEMBL18351811 0.90 SYK (1.00) SYK
SCHEMBL18351838 0.87 SYK (1.00) SYK
SCHEMBL18351839 0.87 SYK (1.00) SYK
SCHEMBL18351872 0.86 SYK (1.00) SYK
SCHEMBL18351869 0.86 SYK (1.00) SYK
SCHEMBL18351841 0.85 SYK (1.00) SYK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9533989-B2 Substituted pyrimidine-5-carboxamides as spleen tyrosine kinase inhibitors Ziarco Pharma Ltd. (GB) 2017-01-03 — — US claimed
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