Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK7 | P49862 | 11/20 | 1.00 |
| ▸ | KLK14 | Q9P0G3 | 11/20 | 1.00 |
| ▸ | KLK5 | Q9Y337 | 11/20 | 1.00 |
| ▸ | CTSG | P08311 | 9/20 | 1.00 |
| ▸ | CTRC | Q99895 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.57 |
| ▸ | C1R | P00736 | 1/20 | 0.56 |
| ▸ | ELANE | P08246 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16946276 | 0.92 | KLK7 (1.00) | KLK7KLK14KLK5CTSGCTRC | |
| SCHEMBL30111990 | 0.92 | KLK7 (1.00) | KLK7KLK14KLK5CTSGCTRC | |
| SCHEMBL22272031 | 0.84 | MEN1 (1.00) | KLK7KLK14KLK5CTSGCTRC | |
| SCHEMBL913416 | 0.82 | KLK7 (1.00) | KLK7KLK14KLK5CTSGCTRC | |
| SCHEMBL912875 | 0.82 | KLK7 (0.85) | KLK7KLK14KLK5CTSGCTRC | |
| SCHEMBL4202365 | 0.82 | MEN1 (0.75) | KLK7KLK14KLK5CTSGCTRC | |
| SCHEMBL914283 | 0.82 | MEN1 (0.75) | KLK7KLK14KLK5CTSGCTRC | |
| SCHEMBL30969124 | 0.80 | KLK7 (0.67) | KLK7KLK14KLK5CTSGCTRC | |
| SCHEMBL8499615 | 0.79 | KMT2A (0.70) | KLK7KLK14KLK5CTSGCTRC | |
| SCHEMBL18353427 | 0.79 | KLK7 (1.00) | KLK7KLK14KLK5CTSGCTRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3097085-B1 | BENZOXAZINONE DERIVATIVES FOR TREATMENT OF SKIN DISEASES | SIXERA PHARMA AB (SE) | 2020-07-29 | — | — | EP | disclosed |
| US-20170267692-A1 | BENZOXAZINONE DERIVATIVES FOR TREATMENT OF SKIN DISEASES | SIXERA PHARMA AB (SE) | 2017-09-21 | — | — | US | disclosed |
| US-20170267692-A1 | BENZOXAZINONE DERIVATIVES FOR TREATMENT OF SKIN DISEASES | SIXERA PHARMA AB (SE) | 2017-09-21 | — | — | US | disclosed |
| US-9695194-B2 | Benzoxazinone derivatives for treatment of skin diseases | SIXERA PHARMA AB (SE) | 2017-07-04 | — | — | US | disclosed |
| US-9695194-B2 | Benzoxazinone derivatives for treatment of skin diseases | SIXERA PHARMA AB (SE) | 2017-07-04 | — | — | US | disclosed |
| US-20170002021-A1 | BENZOXAZINONE DERIVATIVES FOR TREATMENT OF SKIN DISEASES | SIXERA PHARMA AB (SE) | 2017-01-05 | — | — | US | disclosed |
| US-20170002021-A1 | BENZOXAZINONE DERIVATIVES FOR TREATMENT OF SKIN DISEASES | SIXERA PHARMA AB (SE) | 2017-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170267692-A1 | BENZOXAZINONE DERIVATIVES FOR TREATMENT OF SKIN DISEASES | KLK5, KLK14, KLK7 | KLK7 3/4885KLK14 2/4885KLK5 1/4885 |
| US-20170002021-A1 | BENZOXAZINONE DERIVATIVES FOR TREATMENT OF SKIN DISEASES | KLK5, KLK14, KLK7 | KLK7 3/4885KLK14 2/4885KLK5 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.