Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 14/20 | 1.00 |
| ▸ | PDE5A | O76074 | 6/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | HPGD | P15428 | 1/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.64 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | USP2 | O75604 | 1/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.64 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.64 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1064493 | 0.91 | GBA1 (0.82) | GBA1PDE5AALDH1A1MAPK1MEN1 | |
| SCHEMBL16183653 | 0.87 | GBA1 (0.77) | GBA1PDE5AALDH1A1LMNAHPGD | |
| SCHEMBL16183659 | 0.87 | GBA1 (0.77) | GBA1PDE5AALDH1A1LMNAHPGD | |
| SCHEMBL22201478 | 0.87 | GBA1 (0.77) | GBA1PDE5AALDH1A1LMNAHPGD | |
| SCHEMBL7278036 | 0.86 | GBA1 (1.00) | GBA1PDE5AALDH1A1LMNAHPGD | |
| SCHEMBL16183656 | 0.86 | GBA1 (0.74) | GBA1PDE5AALDH1A1LMNAHPGD | |
| SCHEMBL16183660 | 0.86 | GBA1 (0.74) | GBA1PDE5AALDH1A1LMNAHPGD | |
| SCHEMBL18354079 | 0.85 | GBA1 (1.00) | GBA1PDE5AALDH1A1LMNAHPGD | |
| SCHEMBL16183654 | 0.84 | GBA1 (0.72) | GBA1PDE5AALDH1A1LMNAHPGD | |
| SCHEMBL16183655 | 0.83 | GBA1 (0.71) | GBA1PDE5AALDH1A1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10934270-B2 | Substituted quinazoline compounds and uses thereof for modulating glucocerebrosidase activity | NORTHWESTERN UNIVERSITY (US) | 2021-03-02 | — | — | US | disclosed |
| US-20200071292-A1 | SUBSTITUTED QUINAZOLINE COMPOUNDS AND USES THEREOF FOR MODULATING GLUCOCEREBROSIDASE ACTIVITY | NORTHWESTERN UNIVERSITY (US) | 2020-03-05 | — | — | US | disclosed |
| US-10167270-B2 | Substituted quinazoline compounds and uses thereof for modulating glucocerebrosidase activity | NORTHWESTERN UNIVERSITY (US) | 2019-01-01 | — | — | US | disclosed |
| US-20170001976-A1 | SUBSTITUTED QUINAZOLINE COMPOUNDS AND USES THEREOF FOR MODULATING GLUCOCEREBROSIDASE ACTIVITY | NORTHWESTERN UNIVERSITY (US) | 2017-01-05 | — | — | US | disclosed |
| US-20170001976-A1 | SUBSTITUTED QUINAZOLINE COMPOUNDS AND USES THEREOF FOR MODULATING GLUCOCEREBROSIDASE ACTIVITY | NORTHWESTERN UNIVERSITY (US) | 2017-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10934270-B2 | Substituted quinazoline compounds and uses thereof for modulating glucocerebrosidase activity | GBA1, GAA, GBA2 | GBA1 1/4885PDE5A 641/4885ALDH1A1 2347/4885 |
| US-20200071292-A1 | SUBSTITUTED QUINAZOLINE COMPOUNDS AND USES THEREOF FOR MODULATING GLUCOCEREBROSIDASE ACTIVITY | GBA1, GAA, GBA2 | GBA1 1/4885PDE5A 641/4885ALDH1A1 2347/4885 |
| US-20170001976-A1 | SUBSTITUTED QUINAZOLINE COMPOUNDS AND USES THEREOF FOR MODULATING GLUCOCEREBROSIDASE ACTIVITY | GBA1, GAA, GBA2 | GBA1 1/4885PDE5A 641/4885ALDH1A1 2347/4885 |
| US-10167270-B2 | Substituted quinazoline compounds and uses thereof for modulating glucocerebrosidase activity | GBA1, GAA, GBA2 | GBA1 1/4885PDE5A 641/4885ALDH1A1 2347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.