Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 4/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.73 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.73 |
| ▸ | PDE5A | O76074 | 8/20 | 0.67 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.62 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.62 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | METAP1 | P53582 | 2/20 | 0.58 |
| ▸ | JAK2 | O60674 | 1/20 | 0.58 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1064493 | 0.94 | GBA1 (0.82) | GBA1KDM4EMAPK1PDE5AKMT2A | |
| SCHEMBL18354431 | 0.87 | GBA1 (1.00) | GBA1MAPK1PDE5APTGS1TBXAS1 | |
| SCHEMBL22201643 | 0.85 | KDM4E (1.00) | GBA1KDM4EMAPK1PDE5APTGS1 | |
| SCHEMBL1084100 | 0.81 | GBA1 (0.64) | GBA1KDM4EMAPK1PDE5AKMT2A | |
| SCHEMBL1083993 | 0.81 | GBA1 (0.64) | GBA1MAPK1PDE5AKMT2AMETAP1 | |
| SCHEMBL4095086 | 0.81 | GBA1 (0.64) | GBA1KDM4EMAPK1PDE5AKMT2A | |
| SCHEMBL1062608 | 0.81 | PDE5A (1.00) | GBA1KDM4EPDE5APTGS1TBXAS1 | |
| SCHEMBL3459468 | 0.81 | MAPK1 (0.82) | GBA1KDM4EMAPK1PDE5APTGS1 | |
| SCHEMBL6698790 | 0.81 | LATS1 (0.76) | KDM4EMAPK1PDE5APTGS1TBXAS1 | |
| SCHEMBL4237965 | 0.80 | GBA1 (0.62) | GBA1KDM4EMAPK1PDE5AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142748-A1 | METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-07-09 | — | — | WO | disclosed |