Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 3/20 | 0.59 |
| ▸ | BID | P55957 | 3/20 | 0.54 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.54 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.54 |
| ▸ | BAK1 | Q16611 | 2/20 | 0.54 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.54 |
| ▸ | PPARG | P37231 | 1/20 | 0.54 |
| ▸ | EP300 | Q09472 | 1/20 | 0.54 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.54 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.54 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.54 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.54 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.50 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CYSLTR2 | Q9NS75 | 4/20 | 0.49 |
| ▸ | CYSLTR1 | Q9Y271 | 4/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL27594350 | 0.98 | PPARA (0.57) | PPARABIDMCL1BCL2L1BAK1 | |
| Bicarbonate SCHEMBL1838555 | 0.98 | PPARA (0.57) | PPARABIDMCL1BCL2L1BAK1 | |
| Bicarbonate SCHEMBL27513992 | 0.98 | PPARA (0.57) | PPARABIDMCL1BCL2L1BAK1 | |
| Bicarbonate SCHEMBL1835039 | 0.98 | PPARA (0.57) | PPARABIDMCL1BCL2L1BAK1 | |
| Bicarbonate SCHEMBL27543186 | 0.98 | PPARA (0.57) | PPARABIDMCL1BCL2L1BAK1 | |
| Bicarbonate SCHEMBL1839396 | 0.98 | PPARA (0.57) | PPARABIDMCL1BCL2L1BAK1 | |
| Bicarbonate SCHEMBL1839405 | 0.95 | PPARA (0.53) | PPARABIDMCL1BCL2L1BAK1 | |
| Acetic Acid SCHEMBL25188266 | 0.93 | PPARA (0.56) | PPARABIDMCL1BCL2L1BAK1 | |
| Acetic Acid SCHEMBL25190721 | 0.93 | PPARA (0.56) | PPARABIDMCL1BCL2L1BAK1 | |
| Bicarbonate SCHEMBL1838326 | 0.93 | PPARA (0.53) | PPARABIDMCL1BCL2L1BAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100448912-C | Method for producing polyester carbonic ester | BAYER AG (DE) | 2009-01-07 | — | — | CN | claimed |
| CN-1412219-A | Method for producing polyester carbonic ester | BAYER AG (DE) | 2003-04-23 | — | — | CN | claimed |
| EP-3293173-B1 | METHOD FOR PRODUCING ISOCYANATE | ASAHI CHEMICAL IND (JP) | 2021-07-28 | — | — | EP | disclosed |
| EP-3838892-A1 | METHOD FOR PRODUCING ISOCYANATE | Asahi Kasei Kabushiki Kaisha (JP) | 2021-06-23 | — | — | EP | disclosed |
| EP-2980066-B1 | METHOD FOR PRODUCING ISOCYANATE | ASAHI CHEMICAL IND (JP) | 2021-04-21 | — | — | EP | disclosed |
| CN-102093684-B | Polycarbonate Alloys with highly resistance deformability and improved surface property | 科思创德国股份有限公司 | 2019-04-05 | — | — | CN | disclosed |
| EP-3153499-B1 | METHOD FOR PRODUCING N-SUBSTITUTED CARBAMIC ACID ESTER | ASAHI CHEMICAL IND (JP) | 2018-09-19 | — | — | EP | disclosed |
| EP-3293173-A1 | METHOD FOR PRODUCING ISOCYANATE | Asahi Kasei Kabushiki Kaisha (JP) | 2018-03-14 | — | — | EP | disclosed |
| EP-2322504-B9 | PROCESS FOR THE PREPARATION OF N-SUBSTITUTED CARBAMIC ACID ESTER AND PROCESS FOR THE PREPARATION OF ISOCYANATE USING THE N-SUBSTITUTED CARBAMIC ACID ESTER | ASAHI CHEMICAL IND (JP) | 2017-09-06 | — | — | EP | disclosed |
| US-9714215-B2 | Method for producing isocyanate | ASAHI KASEI CHEMICALS CORPORATION (JP) | 2017-07-25 | — | — | US | disclosed |
| EP-3153500-A1 | METHOD FOR PRODUCING ISOCYANATE USING N-SUBSTITUTED CARBAMIC ACID ESTER, AND COMPOSITION FOR TRANSFERRING AND STORING N-SUBSTITUTED CARBAMIC ACID ESTER CONTAINING N-SUBSTITUTED CARBAMIC ACID ESTER AND AROMATIC HYDROXY COMPOUND | ASAHI KASEI KABUSHIKI KAISHA (JP) | 2017-04-12 | — | — | EP | disclosed |
| US-20110133121-A1 | N-Substituted Carbamic Acid Ester Production Method, Isocyanate Production Method Using Such N-Substituted Carbamic Acid Ester, And Composition For Transfer And Storage Of N-Substituted Carbamic Acid Ester Comprising N-Substituted Carbamic Acid Ester and Aromatic Hydroxy Compound | ASAHI KASEI CHEMICALS CORPORATION (JP) | 2011-06-09 | — | — | US | disclosed |
| EP-2322504-A1 | PROCESS FOR THE PREPARATION OF N-SUBSTITUTED CARBAMIC ACID ESTER AND PROCESS FOR THE PREPARATION OF ISOCYANATE USING THE N-SUBSTITUTED CARBAMIC ACID ESTER | Asahi Kasei Chemicals Corporation (JP) | 2011-05-18 | — | — | EP | disclosed |
| CN-100448912-C | Method for producing polyester carbonic ester | BAYER AG (DE) | 2009-01-07 | — | — | CN | disclosed |
| CN-100434453-C | Polycarbonates, polyester carbonates and polyesters containing pendant cycloalkyl-substituted phenols | BAYER MATERIALSCIENCE AG (DE) | 2008-11-19 | — | — | CN | disclosed |
| CN-100393681-C | Polycarbonates and copolycarbonates having reduced water absorption and improved flow capacity, method for the production and use thereof | BAYER MATERIALSCIENCE AG (DE) | 2008-06-11 | — | — | CN | disclosed |
| CN-1871198-A | Polycarbonates and copolycarbonates having reduced water absorption and improved flow capacity, method for the production and use thereof | BAYER MATERIALSCIENCE AG (DE) | 2006-11-29 | — | — | CN | disclosed |
| CN-1729227-A | Polycarbonates, polyester carbonates and polyesters containing pendant cycloalkyl-substituted phenols | BAYER MATERIALSCIENCE AG (DE) | 2006-02-01 | — | — | CN | disclosed |
| CN-1454915-A | Method and apparatus for producing high molecular-weight aliphat makrolan | BAYER AG (DE) | 2003-11-12 | — | — | CN | disclosed |
| CN-1412219-A | Method for producing polyester carbonic ester | BAYER AG (DE) | 2003-04-23 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110133121-A1 | N-Substituted Carbamic Acid Ester Production Method, Isocyanate Production Method Using Such N-Substituted Carbamic Acid Ester, And Composition For Transfer And Storage Of N-Substituted Carbamic Acid Ester Comprising N-Substituted Carbamic Acid Ester and Aromatic Hydroxy Compound | CPS1, ALKBH3, RCC1 | PPARA 772/4885BID 3314/4885MCL1 3708/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.