Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 8/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12142417 | 0.90 | HDAC2 (0.38) | HDAC1HDAC6HDAC8HDAC2 | |
| SCHEMBL12142421 | 0.90 | HDAC2 (0.38) | HDAC1HDAC6HDAC8HDAC2 | |
| SCHEMBL1365143 | 0.83 | HDAC6 (0.59) | HDAC1HDAC6HDAC8HDAC2HDAC3 | |
| SCHEMBL15832592 | 0.83 | HDAC6 (0.46) | HDAC1HDAC6HDAC8HDAC2KDM4E | |
| SCHEMBL17415644 | 0.83 | HDAC6 (0.59) | HDAC1HDAC6HDAC8HDAC2HDAC3 | |
| SCHEMBL16302065 | 0.83 | HDAC6 (0.46) | HDAC1HDAC6HDAC8HDAC2KDM4E | |
| SCHEMBL12142422 | 0.82 | HDAC1 (0.49) | HDAC1HDAC6HDAC8HDAC2HDAC3 | |
| SCHEMBL18356434 | 0.80 | HDAC1 (0.41) | HDAC1HDAC6HDAC8HDAC2HDAC3 | |
| SCHEMBL16330247 | 0.79 | DRD2 (0.45) | HDAC1HDAC6HDAC8HDAC2 | |
| SCHEMBL15832594 | 0.79 | DRD2 (0.45) | HDAC1HDAC6HDAC8HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170000749-A1 | Methods for Treating Cognitive Disorders Using Inhibitors of Histone Deacetylase | FMR LLC | 2017-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170000749-A1 | Methods for Treating Cognitive Disorders Using Inhibitors of Histone Deacetylase | HDAC5, KAT2A, HDAC1 | HDAC1 3/4885HDAC6 11/4885HDAC8 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.