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SCHEMBL18359158

SCHEMBL18359158

CCCCC(C)C(=O)Nc1ccc2c(c1)N(S(=O)(=O)c1ccc(F)cc1)CCC2

nearest known ligand 0.65

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ RORC P51449 17/20 0.65
▸ NR1I2 O75469 4/20 0.61
▸ RORA P35398 4/20 0.61
▸ NR1H2 P55055 4/20 0.61
▸ NR1H3 Q13133 4/20 0.61
▸ RORB Q92753 4/20 0.61
▸ NR1H4 Q96RI1 4/20 0.61
▸ MEN1 O00255 1/20 0.48
▸ KMT2A Q03164 1/20 0.48
▸ SMN1; SMN2 Q16637 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15628949 0.83 RORC (0.66) RORCNR1I2RORANR1H2NR1H3
SCHEMBL5023196 0.82 RORC (0.70) RORCNR1I2RORANR1H2NR1H3
SCHEMBL15628993 0.82 RORC (0.65) RORCNR1I2RORANR1H2NR1H3
SCHEMBL15629002 0.82 RORC (0.65) RORCNR1I2RORANR1H2NR1H3
SCHEMBL15628937 0.82 RORC (0.60) RORCNR1I2RORANR1H2NR1H3
SCHEMBL5021852 0.81 RORC (0.66) RORCNR1I2RORANR1H2NR1H3
SCHEMBL18359167 0.81 RORC (0.62) RORCNR1I2RORANR1H2NR1H3
SCHEMBL15629063 0.81 RORC (0.62) RORCNR1I2RORANR1H2NR1H3
SCHEMBL16823760 0.81 RORC (0.80) RORCNR1I2RORANR1H2NR1H3
SCHEMBL18359194 0.80 RORC (0.60) RORCNR1I2RORANR1H2NR1H3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2638014-B1 N-SULFONYLATED TETRAHYDROQUINOLINES AND RELATED BICYCLIC COMPOUNDS FOR INHIBITION OF ROR-GAMMA ACTIVITY AND THE TREATMENT OF DISEASES LYCERA CORP (US) 2017-01-04 — — EP disclosed