Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3161782 | 0.87 | SRD5A1 (0.48) | SRD5A1ALDH1A1MAPTNPC1LMNA | |
| SCHEMBL15497457 | 0.86 | PRMT5 (0.36) | SRD5A1HTR2AHTR2CHTR2BALOX5 | |
| SCHEMBL5023393 | 0.78 | SRD5A1 (0.45) | SRD5A1ALDH1A1MAPTSMN1; SMN2HTR2A | |
| SCHEMBL23209678 | 0.77 | MAOA (0.46) | ALDH1A1KDM4EHSD17B1 | |
| SCHEMBL20053976 | 0.77 | SRD5A1 (0.42) | SRD5A1ALDH1A1L3MBTL1HTR2AHTR2C | |
| SCHEMBL30718039 | 0.77 | MAOA (0.46) | ALDH1A1KDM4EHSD17B1 | |
| SCHEMBL30205902 | 0.77 | SRD5A1 (0.40) | SRD5A1ALDH1A1MAPTL3MBTL1KDM4E | |
| SCHEMBL30718041 | 0.77 | MAOA (0.46) | ALDH1A1KDM4EHSD17B1 | |
| SCHEMBL11893058 | 0.76 | NOTUM (0.41) | SRD5A1ALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL1994312 | 0.74 | KDM4E (0.49) | SRD5A1ALDH1A1MAPTLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2638014-B1 | N-SULFONYLATED TETRAHYDROQUINOLINES AND RELATED BICYCLIC COMPOUNDS FOR INHIBITION OF ROR-GAMMA ACTIVITY AND THE TREATMENT OF DISEASES | LYCERA CORP (US) | 2017-01-04 | — | — | EP | disclosed |