Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.39 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.39 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20547087 | 0.82 | CYP3A4 (0.42) | MAPTSMN1; SMN2PTGS2KMT2ASCN9A | |
| SCHEMBL18359638 | 0.81 | MEN1 (0.41) | POLBSMN1; SMN2MEN1KMT2AGAA | |
| SCHEMBL18326383 | 0.74 | PDE5A (0.46) | MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL18359666 | 0.74 | CYP3A4 (0.48) | SMN1; SMN2MAPK14ALDH1A1CYP2C9 | |
| SCHEMBL18215329 | 0.72 | ALDH1A1 (0.62) | POLBMEN1KMT2AGAAHTT | |
| SCHEMBL18359596 | 0.72 | CYP3A4 (0.41) | MAPTKMT2ASCN9ALMNAKDM4E | |
| SCHEMBL20547070 | 0.71 | CYP3A4 (0.41) | MAPTKMT2ASCN9ALMNACYP2C9 | |
| SCHEMBL18326374 | 0.71 | HTR2A (0.41) | MAPTSMN1; SMN2MEN1KMT2AHTT | |
| SCHEMBL17502702 | 0.70 | KMT2A (0.65) | POLBMEN1KMT2AGAAHTT | |
| SCHEMBL18215257 | 0.69 | KMT2A (0.63) | POLBMEN1KMT2AGAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017001733-A1 | BICYCLIC HETEROCYCLE DERIVATIVES AS BROMODOMAIN INHIBITORS | ORION CORPORATION (FI) | 2017-01-05 | — | — | WO | disclosed |