Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | APEX1 | P27695 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA7 | P43166 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29046663 | 0.93 | MAPT (0.48) | POLBAPEX1GAALMNAMAPT | |
| SCHEMBL1110997 | 0.87 | GAA (0.57) | POLBAPEX1GAALMNAMAPT | |
| SCHEMBL9248547 | 0.85 | ALPL (0.50) | POLBAPEX1GAALMNAMAPT | |
| SCHEMBL25342477 | 0.85 | CA12 (0.50) | POLBGAALMNAMAPTHPGD | |
| SCHEMBL31024702 | 0.85 | CA12 (0.50) | POLBGAALMNAMAPTHPGD | |
| SCHEMBL14885169 | 0.85 | CA12 (0.50) | POLBGAALMNAMAPTSMN1; SMN2 | |
| SCHEMBL23906095 | 0.83 | CA12 (0.48) | POLBGAALMNAMAPTHPGD | |
| SCHEMBL2650105 | 0.83 | GAA (0.50) | POLBGAALMNAMAPTHPGD | |
| SCHEMBL448027 | 0.82 | GAA (0.47) | POLBAPEX1GAALMNAMAPT | |
| SCHEMBL2771214 | 0.81 | GAA (0.49) | POLBAPEX1GAALMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017004609-A1 | THIADIAZOLE MODULATORS OF S1P AND METHODS OF MAKING AND USING | EXELIXIS, INC. (US) | 2017-01-05 | — | — | WO | disclosed |