Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 20/20 | 0.56 |
| ▸ | MAP4K1 | Q92918 | 14/20 | 0.56 |
| ▸ | KLK1 | P06870 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16891551 | 0.91 | KLKB1 (0.57) | KLKB1MAP4K1 | |
| SCHEMBL20266886 | 0.90 | KLKB1 (0.47) | KLKB1MAP4K1KLK1 | |
| SCHEMBL20266917 | 0.90 | KLKB1 (0.58) | KLKB1MAP4K1KLK1 | |
| SCHEMBL18360084 | 0.90 | KLKB1 (0.45) | KLKB1MAP4K1KLK1 | |
| SCHEMBL20266881 | 0.89 | KLKB1 (0.60) | KLKB1MAP4K1KLK1 | |
| SCHEMBL20266860 | 0.89 | KLKB1 (0.51) | KLKB1MAP4K1KLK1 | |
| SCHEMBL20266924 | 0.88 | KLKB1 (0.58) | KLKB1MAP4K1KLK1 | |
| SCHEMBL20266887 | 0.88 | KLKB1 (0.46) | KLKB1MAP4K1KLK1 | |
| SCHEMBL20266853 | 0.88 | KLKB1 (0.57) | KLKB1MAP4K1 | |
| SCHEMBL20266925 | 0.88 | KLKB1 (0.48) | KLKB1MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180170906-A1 | THERAPEUTIC INHIBITORY COMPOUNDS | ATTUNE PHARMACEUTICALS, INC. | 2018-06-21 | — | — | US | claimed |
| US-10981893-B2 | Therapeutic inhibitory compounds | ATTUNE PHARMACEUTICALS, INC. (US) | 2021-04-20 | — | — | US | disclosed |
| US-10981893-B2 | Therapeutic inhibitory compounds | ATTUNE PHARMACEUTICALS, INC. (US) | 2021-04-20 | — | — | US | disclosed |
| CN-106061480-B | Therapeutic inhibitory compounds | 莱福斯希医药公司 | 2020-02-28 | — | — | CN | disclosed |
| US-20190263783-A1 | THERAPEUTIC INHIBITORY COMPOUNDS | ATTUNE PHARMACEUTICALS, INC. | 2019-08-29 | — | — | US | disclosed |
| US-20190263783-A1 | THERAPEUTIC INHIBITORY COMPOUNDS | ATTUNE PHARMACEUTICALS, INC. | 2019-08-29 | — | — | US | disclosed |
| WO-2017001926-A2 | THERAPEUTIC INHIBITORY COMPOUNDS | LIFESCI PHARMACEUTICALS, INC (BB) | 2017-01-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10981893-B2 | Therapeutic inhibitory compounds | SERPINB1, KLKB1, SERPINE1 | KLKB1 2/4885MAP4K1 271/4885KLK1 5/4885 |
| US-20180170906-A1 | THERAPEUTIC INHIBITORY COMPOUNDS | KLKB1, SERPINB1, SERPINE1 | KLKB1 1/4885MAP4K1 249/4885KLK1 5/4885 |
| US-20190263783-A1 | THERAPEUTIC INHIBITORY COMPOUNDS | SERPINB1, KLKB1, SERPINE1 | KLKB1 2/4885MAP4K1 322/4885KLK1 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.