SERPINB1

Leukocyte elastase inhibitor · P30740 · SERPINB1 on Sugi Atlas →

0 patent compounds predicted against SERPINB1, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours

Clinical trials — most relevant to SERPINB1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Bronchiectasis Alpha-1 Augmentation Trial- Modulating Airway Neutrophil Function PHASE4COMPLETED
Zemaira in Subjects With Emphysema Due to Alpha1-Proteinase Inhibitor Deficiency PHASE4COMPLETED
International Study Evaluating the Safety and Efficacy of Inhaled, Human, Alpha-1 Antitrypsin (AAT) in Alpha-1 Antitrypsin Deficient Patients With Emphysema PHASE2/PHASE3COMPLETED
STOP-COVID19: Superiority Trial Of Protease Inhibition in COVID-19 PHASE3COMPLETED
Phase II/III Study of an Alpha-1 Proteinase Inhibitor (Kamada-API) in Individuals With Alpha-1 Antitrypsin Deficiency PHASE2/PHASE3COMPLETED
The Safety and Tolerability of Alpha-1 Modified Process (MP) In Subjects With Alpha-1-antitrypsin (AAT) Deficiency PHASE3COMPLETED
Efficacy and Safety of GNR-038 vs Berinert® in Patients With Hereditary Angioedema PHASE2/PHASE3WITHDRAWN
Berinert P Study of Subcutaneous Versus Intravenous Administration PHASE3COMPLETED
Study to Evaluate the Safety and Efficacy of Intravenous Glassia® Treatment in Lung Transplantation PHASE2COMPLETED
Single Dose Administration of Alpha-1 Anti-Trypsin for the Amelioration of Organ Injury in Patients Undergoing Cardiac Surgery PHASE1/PHASE2UNKNOWN
Alvelestat (MPH966) for the Treatment of ALpha-1 ANTitrypsin Deficiency PHASE2COMPLETED
Aerosol Combination Therapy of All-trans Retinoic Acid and Isotretinoin as A Novel Treatment for Inducing Neutralizing Antibodies in COVID -19 Infected Patients Better Than Vaccine : An Innovative Treatment PHASE2UNKNOWN
Deposition of Inhaled Prolastin in Cystic Fibrosis Patients PHASE2COMPLETED
A 12-week Study Treating Participants Who Have alpha1-antitrypsin-related COPD With Alvelestat (MPH966) or Placebo. PHASE2COMPLETED
A Study to Evaluate Safety, Tolerability and Pharmacokinetics of Two Different Doses of Alpha1-Proteinase Inhibitor Subcutaneous (Human) 15% in Participants With Alpha1-Antitrypsin Deficiency PHASE1/PHASE2COMPLETED
Phase II, Safety and Efficacy Study of Kamada-alpha-1-antitrypsin (AAT) for Inhalation PHASE2COMPLETED
JDB153 Combined With Serplulimab for Pancreatic Cancer After Standard Treatment Failure PHASE1/PHASE2NOT_YET_RECRUITING
Phase II Study of the Safety and Efficacy of Inhaled Alpha-1 Antitrypsin (AAT ) in Cystic Fibrosis Patients PHASE2COMPLETED
Safety Dose Finding Study of ADVM-043 Gene Therapy to Treat Alpha-1 Antitrypsin (A1AT) Deficiency PHASE1/PHASE2COMPLETED
Effects of Topical SLPI on Skin Wounds PHASE1COMPLETED
Exploratory Clinical Study of Neutrophil Activation Probe (NAP) for Optical Molecular Imaging in Human Lungs EARLY_PHASE1COMPLETED
Breath Condensate Study in Patients With Cystic Fibrosis. nanCOMPLETED
Genomic Research in Alpha-1 Antitrypsin Deficiency nanCOMPLETED
Genetic Mechanisms of Chronic Obstructive Pulmonary Disease (COPD) nanCOMPLETED
Inhaled A1AT in Adult Stable Bronchiectasis nanCOMPLETED
Effect Of Pulmonary Rehabilitation in Patients With Alpha-1 Antitrypsin Deficiency nanCOMPLETED
Evaluating Genetic Factors That May Contribute to Elastin Function and the Development of Chronic Obstructive Pulmonary Disease nanCOMPLETED
The Alpha-1 Foundation's and University of Florida's Alpha-1 Coded Testing (ACT) Study nanRECRUITING
Pancreatic Exocrine Insufficiency in Acute Pancreatitis nanCOMPLETED
Re-evaluation of Some Old Rheumatoid Arthritis Therapy: A Randomized Controlled Trial nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a SERPINB1 binder may also engage these)

ProteinNameSimilarity
Q4G075 1.000 Q4G075 →
Q1JPB0 0.997 Q1JPB0 →
Q8VHP7 0.996 Q8VHP7 →
P80229 0.991 P80229 →
P05619 0.988 P05619 →
Q9D154 0.987 Q9D154 →
SERPINB8 Serpin B8 0.980 landscape →
Q5I0S8 0.979 Q5I0S8 →
O08800 0.976 O08800 →
O02739 0.974 O02739 →
P50453 0.971 P50453 →
Q60854 0.971 Q60854 →
Q5SV42 0.970 Q5SV42 →
SERPINB6 Serpin B6 0.965 landscape →
Q5BIR5 0.965 Q5BIR5 →
P29508 0.960 P29508 →
Q52L45 0.959 Q52L45 →
P48594 0.959 P48594 →
Q5R899 0.959 Q5R899 →
Q4R3G2 0.957 Q4R3G2 →
Q9UIV8 0.954 Q9UIV8 →
B4USX2 0.944 B4USX2 →
O00394 0.940 O00394 →
P17475 0.940 P17475 →
A5PJK0 0.939 A5PJK0 →
Q96P15 0.937 Q96P15 →
P97277 0.937 P97277 →
P01013 0.933 P01013 →
P01009 0.932 P01009 →
Q8K1K6 0.931 Q8K1K6 →