Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 10/20 | 0.44 |
| ▸ | S1PR5 | Q9H228 | 6/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 4/20 | 0.42 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
| ▸ | GRK5 | P34947 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | EED | O75530 | 1/20 | 0.40 |
| ▸ | PDE8A | O60658 | 1/20 | 0.39 |
| ▸ | PDE8B | O95263 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15084392 | 0.84 | S1PR1 (0.46) | ALDH1A1KDM4ETSHRTDP1L3MBTL1 | |
| SCHEMBL10212863 | 0.83 | S1PR5 (0.47) | ALDH1A1KDM4ETSHRTDP1L3MBTL1 | |
| SCHEMBL15081969 | 0.76 | EED (0.39) | ALDH1A1KDM4ETSHRTDP1L3MBTL1 | |
| SCHEMBL15084388 | 0.75 | CD274 (0.45) | KDM4EL3MBTL1MEN1KMT2A | |
| SCHEMBL2728895 | 0.74 | CD274 (0.45) | ALDH1A1KDM4ETSHRTDP1L3MBTL1 | |
| SCHEMBL15084389 | 0.73 | ALDH1A1 (0.46) | ALDH1A1KDM4ETSHRTDP1L3MBTL1 | |
| SCHEMBL15081966 | 0.71 | ALDH1A1 (0.41) | ALDH1A1KDM4ETSHRTDP1L3MBTL1 | |
| SCHEMBL807578 | 0.71 | ALDH1A1 (0.43) | ALDH1A1KDM4ETSHRTDP1L3MBTL1 | |
| SCHEMBL15084390 | 0.70 | EED (0.43) | ALDH1A1KDM4ETSHRPOLBSMN1; SMN2 | |
| SCHEMBL807604 | 0.70 | ALDH1A1 (0.50) | ALDH1A1KDM4ETDP1L3MBTL1S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2615916-B1 | FUSED PYRAZOLE DERIVATIVES AS NOVEL ERK INHIBITORS | MERCK SHARP & DOHME (US) | 2017-01-04 | — | — | EP | disclosed |