Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18360589 | 0.91 | — | — | |
| SCHEMBL18360586 | 0.88 | PKM (0.37) | KMT2AMEN1PKM | |
| SCHEMBL18360587 | 0.87 | MAPK1 (0.46) | — | |
| SCHEMBL18360601 | 0.86 | MEN1 (0.42) | KMT2AMEN1 | |
| SCHEMBL18360581 | 0.83 | — | — | |
| SCHEMBL18360688 | 0.82 | — | — | |
| SCHEMBL18360582 | 0.80 | — | — | |
| SCHEMBL807466 | 0.79 | — | — | |
| SCHEMBL15065324 | 0.79 | — | — | |
| SCHEMBL18360605 | 0.79 | MAPK1 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2615916-B1 | FUSED PYRAZOLE DERIVATIVES AS NOVEL ERK INHIBITORS | MERCK SHARP & DOHME (US) | 2017-01-04 | — | — | EP | disclosed |