Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL807354 | 0.82 | BRD4 (0.49) | BRD4CREBBP | |
| SCHEMBL807229 | 0.72 | BRD4 (0.59) | BRD4CREBBPMAPK1 | |
| SCHEMBL17877208 | 0.72 | BRD4 (0.71) | BRD4CREBBPMAPK1 | |
| SCHEMBL10801839 | 0.72 | MAPK1 (0.76) | BRD4CREBBPMAPK1 | |
| SCHEMBL807352 | 0.72 | MAPK1 (0.58) | BRD4CREBBPMAPK1 | |
| SCHEMBL807469 | 0.71 | PIP5K1C (0.51) | BRD4CREBBP | |
| SCHEMBL15065180 | 0.71 | BRD4 (0.49) | BRD4CREBBP | |
| SCHEMBL15084434 | 0.71 | BRD4 (0.49) | BRD4CREBBP | |
| SCHEMBL15065182 | 0.71 | BRD4 (0.49) | BRD4CREBBP | |
| SCHEMBL15065178 | 0.71 | BRD4 (0.49) | BRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2615916-B1 | FUSED PYRAZOLE DERIVATIVES AS NOVEL ERK INHIBITORS | MERCK SHARP & DOHME (US) | 2017-01-04 | — | — | EP | disclosed |