Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 19/20 | 0.51 |
| ▸ | NTRK3 | Q16288 | 10/20 | 0.51 |
| ▸ | NTRK2 | Q16620 | 8/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18361546 | 0.93 | NTRK1 (0.49) | NTRK1NTRK3NTRK2TGFBR1 | |
| SCHEMBL20355678 | 0.93 | NTRK1 (0.49) | NTRK1NTRK3NTRK2TGFBR1 | |
| SCHEMBL18361444 | 0.92 | NTRK1 (0.49) | NTRK1NTRK3NTRK2 | |
| SCHEMBL16947092 | 0.88 | NTRK1 (0.46) | NTRK1NTRK3NTRK2 | |
| SCHEMBL23037379 | 0.87 | NTRK1 (0.55) | NTRK1NTRK3NTRK2 | |
| SCHEMBL23037381 | 0.87 | NTRK1 (0.55) | NTRK1NTRK3NTRK2 | |
| SCHEMBL18361545 | 0.85 | NTRK1 (0.43) | NTRK1NTRK3NTRK2 | |
| SCHEMBL16946813 | 0.85 | NTRK1 (0.43) | NTRK1NTRK3NTRK2 | |
| SCHEMBL21815180 | 0.85 | NTRK1 (0.43) | NTRK1NTRK3NTRK2 | |
| SCHEMBL20359954 | 0.85 | NTRK1 (0.43) | NTRK1NTRK3NTRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017004342-A1 | CHIRAL DIARYL MACROCYCLES AS MODULATORS OF PROTEIN KINASES | TP THERAPEUTICS, INC. (US) | 2017-01-05 | — | — | WO | disclosed |