Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18367152 | 0.75 | PIM1 (0.36) | MAPK14MAP4K1 | |
| SCHEMBL30587478 | 0.75 | PIM1 (0.36) | MAPK14MAP4K1 | |
| SCHEMBL18376126 | 0.73 | MAPK14 (0.41) | MAPK14MAP4K1 | |
| SCHEMBL19658858 | 0.72 | MAPK14 (0.42) | MAPK14 | |
| SCHEMBL18367156 | 0.72 | CYP11B1 (0.39) | MAPK14MAP4K1 | |
| SCHEMBL30587515 | 0.72 | CYP11B1 (0.39) | MAPK14MAP4K1 | |
| SCHEMBL18376127 | 0.71 | IRAK4 (0.35) | MAPK14MAP4K1 | |
| SCHEMBL1888378 | 0.61 | ERN1 (0.40) | MAPK14 | |
| SCHEMBL29703245 | 0.61 | NPC1 (0.55) | MAPK14 | |
| SCHEMBL25343285 | 0.59 | SLC2A1 (0.43) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170008877-A1 | BICYCLIC LACTAMS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2017-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170008877-A1 | BICYCLIC LACTAMS AND METHODS OF USE THEREOF | LSS, LPXN, CYP1B1 | MAPK14 4704/4885MAP4K1 4741/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.