Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | BCR | P11274 | 1/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.33 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.33 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18367152 | 1.00 | PIM1 (0.36) | PIM1PIM3PIM2MAPTABL1 | |
| SCHEMBL18376127 | 0.78 | IRAK4 (0.35) | MAP4K1MAPK14 | |
| SCHEMBL30587534 | 0.77 | KMT2A (0.35) | MAPTMAPK14SMN1; SMN2PDE7AKMT2A | |
| SCHEMBL18367151 | 0.77 | KMT2A (0.35) | MAPTMAPK14SMN1; SMN2PDE7AKMT2A | |
| SCHEMBL18376126 | 0.77 | MAPK14 (0.41) | MAP4K1MAPK14MAPKAPK2MAPK8MAPK10 | |
| SCHEMBL343580 | 0.76 | KDM4E (0.56) | MAPTSMN1; SMN2KMT2A | |
| SCHEMBL18367153 | 0.75 | MAPK14 (0.34) | MAP4K1MAPK14 | |
| SCHEMBL18367156 | 0.73 | CYP11B1 (0.39) | MAPTMAP4K1MAPK14MAPKAPK2KMT2A | |
| SCHEMBL30587515 | 0.73 | CYP11B1 (0.39) | MAPTMAP4K1MAPK14MAPKAPK2KMT2A | |
| SCHEMBL29387304 | 0.72 | IRAK4 (0.42) | PIM1PIM3PIM2PIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111269221-B | Bicyclic lactams and methods of use thereof | 豪夫迈·罗氏有限公司 | 2023-09-26 | — | — | CN | disclosed |