Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | SYK | P43405 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13855801 | 0.89 | POLB (0.59) | POLBSYKKDM4ETSHRALDH1A1 | |
| SCHEMBL18374004 | 0.87 | SMN1; SMN2 (0.67) | KDM4ETSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL12409038 | 0.83 | SYK (0.71) | POLBSYKKDM4ETSHRALDH1A1 | |
| SCHEMBL13963827 | 0.83 | SYK (0.71) | POLBSYKKDM4ETSHRALDH1A1 | |
| SCHEMBL13723046 | 0.83 | POLB (0.63) | POLBSYKKDM4ETSHRALDH1A1 | |
| SCHEMBL31539648 | 0.83 | ALDH1A1 (0.59) | POLBKDM4ETSHRALDH1A1EPHX2 | |
| SCHEMBL15872036 | 0.83 | SMN1; SMN2 (0.74) | POLBSYKKDM4ETSHRALDH1A1 | |
| SCHEMBL20347952 | 0.83 | KDM4E (0.55) | POLBKDM4ETSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL20376289 | 0.83 | HTT (0.57) | POLBSYKKDM4ETSHRALDH1A1 | |
| SCHEMBL13855802 | 0.82 | KDM4E (0.67) | POLBKDM4ETSHRALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018098204-A1 | 6-MEMBERED URACIL ISOSTERES | CV6 THERAPEUTICS (NI) LIMITED (GB) | 2018-05-31 | — | — | WO | disclosed |
| WO-2017006271-A1 | DEOXYURIDINE TRIPHOSPHATASE INHIBITORS CONTAINING AMINO SULFONYL LINKAGE | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2017-01-12 | — | — | WO | disclosed |