Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.68 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.63 |
| ▸ | JUN | P05412 | 4/20 | 0.61 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.61 |
| ▸ | CDK4 | P11802 | 2/20 | 0.56 |
| ▸ | CCND1 | P24385 | 2/20 | 0.56 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.56 |
| ▸ | CDK2 | P24941 | 2/20 | 0.56 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.56 |
| ▸ | TTK | P33981 | 1/20 | 0.56 |
| ▸ | SYK | P43405 | 2/20 | 0.54 |
| ▸ | JAK2 | O60674 | 7/20 | 0.54 |
| ▸ | JAK3 | P52333 | 1/20 | 0.54 |
| ▸ | BRD4 | O60885 | 3/20 | 0.53 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29372582 | 1.00 | EGFR (0.68) | EGFRMAPK10JUNMAPK8CDK4 | |
| SCHEMBL18376602 | 0.91 | EGFR (0.71) | EGFRMAPK10CDK4CCND1CCNE1 | |
| SCHEMBL18376258 | 0.90 | EGFR (0.61) | EGFRMAPK10JUNMAPK8CDK4 | |
| SCHEMBL18376646 | 0.89 | EGFR (0.66) | EGFRMAPK10CDK4CCND1CCNE1 | |
| SCHEMBL29368349 | 0.89 | EGFR (0.66) | EGFRMAPK10CDK4CCND1CCNE1 | |
| SCHEMBL29370824 | 0.89 | EGFR (0.66) | EGFRMAPK10CDK4CCND1CCNE1 | |
| SCHEMBL28696412 | 0.89 | EGFR (0.66) | EGFRMAPK10CDK4CCND1CCNE1 | |
| SCHEMBL29576513 | 0.88 | EGFR (0.72) | EGFRMAPK10CDK4CCND1CCNE1 | |
| SCHEMBL18376769 | 0.86 | MAPK10 (0.55) | EGFRMAPK10JUNMAPK8CDK2 | |
| SCHEMBL20807685 | 0.85 | EGFR (0.79) | EGFRMAPK10CDK4CCND1CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113999180-A | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2022-02-01 | — | — | CN | claimed |
| CN-113999180-B | Quinazoline compound, intermediate, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2024-03-26 | — | — | CN | disclosed |
| CN-113999180-A | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2022-02-01 | — | — | CN | disclosed |
| CN-106316965-B | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2021-08-27 | — | — | CN | disclosed |
| WO-2017005137-A1 | QUINAZOLINE COMPOUND, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USES THEREOF | 吉林大学 | 2017-01-12 | — | — | WO | disclosed |