Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 7/20 | 0.55 |
| ▸ | MAPK8 | P45983 | 6/20 | 0.55 |
| ▸ | JUN | P05412 | 5/20 | 0.55 |
| ▸ | JAK2 | O60674 | 10/20 | 0.53 |
| ▸ | JAK3 | P52333 | 9/20 | 0.53 |
| ▸ | JAK1 | P23458 | 4/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | TYK2 | P29597 | 2/20 | 0.51 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.51 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.51 |
| ▸ | TTK | P33981 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | CIT | O14578 | 1/20 | 0.47 |
| ▸ | GAK | O14976 | 1/20 | 0.47 |
| ▸ | OPA1 | O60313 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | STK16 | O75716 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18376774 | 0.93 | MAPK10 (0.51) | MAPK10MAPK8JUNJAK2JAK3 | |
| SCHEMBL18376259 | 0.92 | JAK3 (0.53) | MAPK10MAPK8JUNJAK2JAK3 | |
| SCHEMBL18376257 | 0.91 | JAK3 (0.54) | MAPK10MAPK8JUNJAK2JAK3 | |
| SCHEMBL18376766 | 0.90 | EGFR (0.57) | MAPK10MAPK8JUNJAK2JAK3 | |
| SCHEMBL29205083 | 0.90 | MAPK10 (0.48) | MAPK10MAPK8JUNJAK2JAK3 | |
| SCHEMBL18376650 | 0.90 | EGFR (0.52) | MAPK10MAPK8JUNJAK2JAK3 | |
| SCHEMBL29372582 | 0.86 | EGFR (0.68) | MAPK10MAPK8JUNJAK2JAK3 | |
| SCHEMBL18376592 | 0.86 | EGFR (0.68) | MAPK10MAPK8JUNJAK2JAK3 | |
| SCHEMBL18376854 | 0.84 | EGFR (0.63) | MAPK10JAK2JAK3JAK1EGFR | |
| SCHEMBL18376862 | 0.82 | EGFR (0.48) | JAK2JAK3EGFRFGFR2TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017005137-A1 | QUINAZOLINE COMPOUND, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USES THEREOF | 吉林大学 | 2017-01-12 | — | — | WO | disclosed |