Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | JAK1 | P23458 | 1/20 | 0.48 |
| ▸ | TYK2 | P29597 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
| ▸ | ALOX5AP | P20292 | 10/20 | 0.47 |
| ▸ | FEN1 | P39748 | 10/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.45 |
| ▸ | ATR | Q13535 | 1/20 | 0.42 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 2/20 | 0.38 |
| ▸ | CHUK | O15111 | 2/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18376805 | 0.82 | MAPK10 (0.57) | JAK2JAK1TYK2JAK3DRD1 | |
| SCHEMBL18376841 | 0.79 | MAPK10 (0.53) | JAK2JAK1TYK2JAK3PTK2 | |
| SCHEMBL18376248 | 0.76 | RORC (0.53) | JAK2JAK1TYK2JAK3IKBKB | |
| SCHEMBL30634004 | 0.76 | ADORA1 (0.49) | JAK3 | |
| SCHEMBL15228702 | 0.75 | LCK (0.41) | JAK2JAK3ALOX5APFEN1L3MBTL1 | |
| SCHEMBL29372601 | 0.74 | KMT2A (0.60) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL18376867 | 0.74 | KMT2A (0.60) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL18376610 | 0.73 | MAPK10 (0.46) | JAK1JAK3 | |
| SCHEMBL29371298 | 0.72 | JAK2 (0.51) | JAK2JAK1JAK3PTK2 | |
| SCHEMBL18377076 | 0.72 | JAK2 (0.65) | JAK2JAK1JAK3PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017005137-A1 | QUINAZOLINE COMPOUND, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USES THEREOF | 吉林大学 | 2017-01-12 | — | — | WO | disclosed |