Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 5/20 | 0.57 |
| ▸ | BRD4 | O60885 | 2/20 | 0.57 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.53 |
| ▸ | BRAF | P15056 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | JAK3 | P52333 | 4/20 | 0.50 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.49 |
| ▸ | SRC | P12931 | 6/20 | 0.49 |
| ▸ | YES1 | P07947 | 4/20 | 0.49 |
| ▸ | KDR | P35968 | 3/20 | 0.49 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.49 |
| ▸ | ABL1 | P00519 | 2/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | RAF1 | P04049 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | FYN | P06241 | 1/20 | 0.49 |
| ▸ | LYN | P07948 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18377069 | 1.00 | JAK2 (0.57) | JAK2BRD4FGFR2BRAFHRH3 | |
| SCHEMBL29371925 | 0.91 | BRAF (0.60) | JAK2BRD4FGFR2BRAFHRH3 | |
| SCHEMBL18377066 | 0.91 | BRAF (0.60) | JAK2BRD4FGFR2BRAFHRH3 | |
| SCHEMBL18376789 | 0.89 | BRAF (0.51) | JAK2FGFR2BRAFHRH3JAK3 | |
| SCHEMBL18377042 | 0.88 | BRAF (0.55) | JAK2BRD4FGFR2BRAFJAK3 | |
| SCHEMBL29370829 | 0.88 | BRAF (0.55) | JAK2BRD4FGFR2BRAFJAK3 | |
| SCHEMBL16513615 | 0.88 | MAPK10 (0.59) | JAK2BRD4FGFR2BRAFJAK3 | |
| SCHEMBL18377046 | 0.86 | BRD4 (0.63) | JAK2BRD4JAK3KDREGFR | |
| SCHEMBL18376830 | 0.85 | JAK2 (0.68) | JAK2BRD4FGFR2BRAFHRH3 | |
| SCHEMBL18376601 | 0.85 | BRD4 (0.57) | JAK2BRD4FGFR2JAK3FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113999180-A | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2022-02-01 | — | — | CN | claimed |
| CN-113999180-B | Quinazoline compound, intermediate, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2024-03-26 | — | — | CN | disclosed |
| CN-113999180-A | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2022-02-01 | — | — | CN | disclosed |
| CN-106316965-B | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2021-08-27 | — | — | CN | disclosed |
| WO-2017005137-A1 | QUINAZOLINE COMPOUND, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USES THEREOF | 吉林大学 | 2017-01-12 | — | — | WO | disclosed |