Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 11/20 | 0.68 |
| ▸ | JAK3 | P52333 | 11/20 | 0.68 |
| ▸ | PTK2 | Q05397 | 9/20 | 0.68 |
| ▸ | BRAF | P15056 | 2/20 | 0.52 |
| ▸ | SRC | P12931 | 4/20 | 0.52 |
| ▸ | BRD4 | O60885 | 3/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.52 |
| ▸ | ABL1 | P00519 | 3/20 | 0.52 |
| ▸ | EGFR | P00533 | 3/20 | 0.52 |
| ▸ | YES1 | P07947 | 3/20 | 0.52 |
| ▸ | KDR | P35968 | 3/20 | 0.52 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.52 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.52 |
| ▸ | AXL | P30530 | 2/20 | 0.52 |
| ▸ | MERTK | Q12866 | 2/20 | 0.52 |
| ▸ | LCK | P06239 | 2/20 | 0.52 |
| ▸ | FYN | P06241 | 2/20 | 0.52 |
| ▸ | LYN | P07948 | 2/20 | 0.52 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29371925 | 0.92 | BRAF (0.60) | JAK2JAK3PTK2BRAFSRC | |
| SCHEMBL18377066 | 0.92 | BRAF (0.60) | JAK2JAK3PTK2BRAFSRC | |
| SCHEMBL18376808 | 0.91 | JAK2 (0.57) | JAK2JAK3PTK2BRAFSRC | |
| SCHEMBL18376653 | 0.91 | JAK2 (0.57) | JAK2JAK3PTK2BRAFSRC | |
| SCHEMBL18377042 | 0.89 | BRAF (0.55) | JAK2JAK3PTK2BRAFSRC | |
| SCHEMBL29370829 | 0.89 | BRAF (0.55) | JAK2JAK3PTK2BRAFSRC | |
| SCHEMBL28679014 | 0.85 | JAK2 (0.51) | JAK2JAK3PTK2BRAFSRC | |
| SCHEMBL18377069 | 0.85 | JAK2 (0.57) | JAK2JAK3PTK2BRAFSRC | |
| SCHEMBL18376804 | 0.85 | JAK2 (0.57) | JAK2JAK3PTK2BRAFSRC | |
| SCHEMBL18376823 | 0.85 | SRC (0.53) | JAK2JAK3PTK2BRAFSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017005137-A1 | QUINAZOLINE COMPOUND, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USES THEREOF | 吉林大学 | 2017-01-12 | — | — | WO | disclosed |