Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.60 |
| ▸ | JAK2 | O60674 | 14/20 | 0.56 |
| ▸ | JAK3 | P52333 | 13/20 | 0.56 |
| ▸ | JAK1 | P23458 | 2/20 | 0.56 |
| ▸ | PTK2 | Q05397 | 11/20 | 0.55 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.51 |
| ▸ | CDK2 | P24941 | 3/20 | 0.51 |
| ▸ | CDK9 | P50750 | 3/20 | 0.51 |
| ▸ | BRD4 | O60885 | 2/20 | 0.51 |
| ▸ | CDK1 | P06493 | 2/20 | 0.51 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.51 |
| ▸ | CDK7 | P50613 | 1/20 | 0.49 |
| ▸ | CCNH | P51946 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18376835 | 0.92 | EGFR (0.58) | EGFRJAK2JAK3JAK1PTK2 | |
| SCHEMBL29370824 | 0.91 | EGFR (0.66) | EGFRJAK2JAK3JAK1PTK2 | |
| SCHEMBL28696412 | 0.91 | EGFR (0.66) | EGFRJAK2JAK3JAK1PTK2 | |
| SCHEMBL18376249 | 0.91 | EGFR (0.61) | EGFRJAK2JAK3JAK1PTK2 | |
| SCHEMBL29368834 | 0.90 | EGFR (0.62) | EGFRJAK2JAK3JAK1CCNT1 | |
| SCHEMBL18376840 | 0.90 | EGFR (0.62) | EGFRJAK2JAK3JAK1CCNT1 | |
| SCHEMBL28696326 | 0.89 | JAK2 (0.67) | JAK2JAK3JAK1PTK2ABCB1 | |
| SCHEMBL18376831 | 0.89 | EGFR (0.56) | EGFRJAK2JAK3JAK1PTK2 | |
| SCHEMBL18376833 | 0.89 | EGFR (0.56) | EGFRJAK2JAK3JAK1PTK2 | |
| SCHEMBL18376844 | 0.89 | EGFR (0.65) | EGFRJAK2JAK3CCNT1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113999180-B | Quinazoline compound, intermediate, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2024-03-26 | — | — | CN | disclosed |
| WO-2017005137-A1 | QUINAZOLINE COMPOUND, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USES THEREOF | 吉林大学 | 2017-01-12 | — | — | WO | disclosed |