Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.56 |
| ▸ | BRD4 | O60885 | 8/20 | 0.52 |
| ▸ | JAK2 | O60674 | 6/20 | 0.52 |
| ▸ | CCNT1 | O60563 | 7/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.49 |
| ▸ | CDK2 | P24941 | 7/20 | 0.49 |
| ▸ | CDK9 | P50750 | 7/20 | 0.49 |
| ▸ | JAK3 | P52333 | 4/20 | 0.48 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.48 |
| ▸ | CDK1 | P06493 | 4/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.48 |
| ▸ | FLT3 | P36888 | 2/20 | 0.48 |
| ▸ | JAK1 | P23458 | 2/20 | 0.48 |
| ▸ | CDK7 | P50613 | 3/20 | 0.48 |
| ▸ | CCNH | P51946 | 3/20 | 0.48 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.48 |
| ▸ | BUB1B | O60566 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
| ▸ | BRD2 | P25440 | 1/20 | 0.48 |
| ▸ | WEE1 | P30291 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18376835 | 0.91 | EGFR (0.58) | EGFRBRD4JAK2CCNT1CCNA2 | |
| SCHEMBL29205109 | 0.91 | EGFR (0.58) | EGFRBRD4JAK2CCNT1CCNA2 | |
| SCHEMBL18376247 | 0.90 | BRD4 (0.60) | BRD4JAK2JAK3PTK2FLT3 | |
| SCHEMBL18376829 | 0.89 | EGFR (0.60) | EGFRBRD4JAK2CCNT1CCNA2 | |
| SCHEMBL18376831 | 0.89 | EGFR (0.56) | EGFRBRD4JAK2CCNT1CCNA2 | |
| SCHEMBL18376763 | 0.88 | PTK2 (0.55) | BRD4JAK2JAK3PTK2FLT3 | |
| SCHEMBL18376784 | 0.87 | TBK1 (0.49) | EGFRBRD4JAK2JAK3PTK2 | |
| SCHEMBL28690545 | 0.87 | EGFR (0.54) | EGFRBRD4JAK2CCNT1CCNA2 | |
| SCHEMBL18376748 | 0.86 | EGFR (0.57) | EGFRBRD4JAK2CCNT1CCNA2 | |
| SCHEMBL18376840 | 0.86 | EGFR (0.62) | EGFRBRD4JAK2CCNT1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017005137-A1 | QUINAZOLINE COMPOUND, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USES THEREOF | 吉林大学 | 2017-01-12 | — | — | WO | disclosed |