Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.49 |
| ▸ | JAK2 | O60674 | 3/20 | 0.49 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.48 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | CDK4 | P11802 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | TYK2 | P29597 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.46 |
| ▸ | JUN | P05412 | 4/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.46 |
| ▸ | TTK | P33981 | 3/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | CTSC | P53634 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29370835 | 1.00 | BRD4 (0.49) | BRD4JAK2HRH4FGFR4AURKA | |
| SCHEMBL18377046 | 0.88 | BRD4 (0.63) | BRD4JAK2FGFR4AURKACDK4 | |
| SCHEMBL18376246 | 0.87 | JAK2 (0.56) | BRD4JAK2FGFR4AURKACDK4 | |
| SCHEMBL29371334 | 0.87 | JAK2 (0.56) | BRD4JAK2FGFR4AURKACDK4 | |
| SCHEMBL28120334 | 0.84 | BRD4 (0.51) | BRD4JAK2HRH4FGFR4AURKA | |
| SCHEMBL29371298 | 0.84 | JAK2 (0.51) | BRD4JAK2FGFR4AURKACDK4 | |
| SCHEMBL18376806 | 0.84 | JAK2 (0.51) | BRD4JAK2FGFR4AURKACDK4 | |
| SCHEMBL18376659 | 0.83 | BRD4 (0.49) | BRD4JAK2HRH4FGFR4AURKA | |
| SCHEMBL18376598 | 0.82 | FGFR4 (0.59) | JAK2FGFR4JAK3KDR | |
| SCHEMBL29371309 | 0.82 | FGFR4 (0.59) | JAK2FGFR4JAK3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113999180-A | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2022-02-01 | — | — | CN | claimed |
| CN-113999180-B | Quinazoline compound, intermediate, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2024-03-26 | — | — | CN | disclosed |
| CN-113999180-A | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2022-02-01 | — | — | CN | disclosed |
| CN-106316965-B | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2021-08-27 | — | — | CN | disclosed |
| WO-2017005137-A1 | QUINAZOLINE COMPOUND, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USES THEREOF | 吉林大学 | 2017-01-12 | — | — | WO | disclosed |