Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 2/20 | 0.59 |
| ▸ | AXL | P30530 | 9/20 | 0.58 |
| ▸ | MERTK | Q12866 | 7/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.51 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | MET | P08581 | 1/20 | 0.49 |
| ▸ | CHKA | P35790 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 3/20 | 0.49 |
| ▸ | JAK3 | P52333 | 2/20 | 0.49 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18376598 | 1.00 | FGFR4 (0.59) | FGFR4AXLMERTKFGFR1MAP3K11 | |
| SCHEMBL29368456 | 0.91 | ACP1 (0.56) | FGFR4AXLMAP3K11JAK2JAK3 | |
| SCHEMBL18377043 | 0.91 | ACP1 (0.56) | FGFR4AXLMAP3K11JAK2JAK3 | |
| SCHEMBL18376789 | 0.89 | BRAF (0.51) | FGFR4AXLMERTKFGFR1KDR | |
| SCHEMBL18377046 | 0.86 | BRD4 (0.63) | FGFR4KDRJAK2JAK3 | |
| SCHEMBL18376798 | 0.85 | JAK2 (0.55) | FGFR4AXLMERTKFGFR1JAK2 | |
| SCHEMBL28698465 | 0.84 | FGFR1 (0.50) | FGFR4AXLMERTKFGFR1KDR | |
| SCHEMBL29371294 | 0.84 | MAPK10 (0.60) | KDRJAK2JAK3PTK2 | |
| SCHEMBL18376750 | 0.84 | MAPK10 (0.60) | KDRJAK2JAK3PTK2 | |
| SCHEMBL18377042 | 0.82 | BRAF (0.55) | FGFR4AXLFGFR1KDRJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113999180-A | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2022-02-01 | — | — | CN | claimed |
| CN-113999180-B | Quinazoline compound, intermediate, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2024-03-26 | — | — | CN | disclosed |
| CN-113999180-A | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2022-02-01 | — | — | CN | disclosed |