Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 6/20 | 0.56 |
| ▸ | JAK3 | P52333 | 3/20 | 0.56 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.56 |
| ▸ | TTK | P33981 | 1/20 | 0.56 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.51 |
| ▸ | JUN | P05412 | 4/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.51 |
| ▸ | BRD4 | O60885 | 3/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.49 |
| ▸ | CDK2 | P24941 | 4/20 | 0.49 |
| ▸ | CDK9 | P50750 | 4/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.49 |
| ▸ | CDK1 | P06493 | 1/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18376851 | 0.91 | JAK2 (0.54) | JAK2JAK3PTK2TTKMAPK10 | |
| SCHEMBL29371808 | 0.90 | JAK2 (0.58) | JAK2JAK3PTK2TTKBRD4 | |
| SCHEMBL18377030 | 0.90 | JAK2 (0.58) | JAK2JAK3PTK2TTKBRD4 | |
| SCHEMBL18376753 | 0.88 | PTK2 (0.56) | JAK2JAK3PTK2TTKBRD4 | |
| SCHEMBL18376835 | 0.87 | EGFR (0.58) | JAK2JAK3PTK2BRD4CCNT1 | |
| SCHEMBL29370855 | 0.85 | TTK (0.61) | JAK2JAK3PTK2TTKMAPK10 | |
| SCHEMBL18376727 | 0.85 | TTK (0.61) | JAK2JAK3PTK2TTKMAPK10 | |
| SCHEMBL18376853 | 0.85 | JAK3 (0.58) | JAK2JAK3PTK2MAPK10CDK2 | |
| SCHEMBL18376252 | 0.85 | TTK (0.65) | JAK2JAK3PTK2TTKMAPK10 | |
| SCHEMBL30859695 | 0.85 | TTK (0.65) | JAK2JAK3PTK2TTKMAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017005137-A1 | QUINAZOLINE COMPOUND, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USES THEREOF | 吉林大学 | 2017-01-12 | — | — | WO | disclosed |