Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.52 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.47 |
| ▸ | JUN | P05412 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 4/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 2/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | TTK | P33981 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29370836 | 1.00 | KDR (0.52) | KDRRIPK2PIK3CBPIK3CGPIK3CA | |
| SCHEMBL18377040 | 0.90 | PIK3CG (0.60) | KDRRIPK2PIK3CBPIK3CGPIK3CA | |
| SCHEMBL29370809 | 0.90 | PIK3CG (0.60) | KDRRIPK2PIK3CBPIK3CGPIK3CA | |
| SCHEMBL18377036 | 0.87 | MAPK10 (0.55) | KDRRIPK2PIK3CBPIK3CGPIK3CA | |
| SCHEMBL29371938 | 0.87 | MAPK10 (0.55) | KDRRIPK2PIK3CBPIK3CGPIK3CA | |
| SCHEMBL18376750 | 0.87 | MAPK10 (0.60) | KDRRIPK2PIK3CBPIK3CGPIK3CA | |
| SCHEMBL29371294 | 0.87 | MAPK10 (0.60) | KDRRIPK2PIK3CBPIK3CGPIK3CA | |
| SCHEMBL28120317 | 0.86 | MAPK10 (0.50) | RIPK2PIK3CBPIK3CGPIK3CAMAPK10 | |
| SCHEMBL18377044 | 0.84 | RIPK2 (0.69) | KDRRIPK2PIK3CBPIK3CGPIK3CA | |
| SCHEMBL29372255 | 0.84 | RIPK2 (0.69) | KDRRIPK2PIK3CBPIK3CGPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113999180-B | Quinazoline compound, intermediate, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2024-03-26 | — | — | CN | disclosed |
| CN-113999180-A | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2022-02-01 | — | — | CN | disclosed |
| CN-106316965-B | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2021-08-27 | — | — | CN | disclosed |
| WO-2017005137-A1 | QUINAZOLINE COMPOUND, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USES THEREOF | 吉林大学 | 2017-01-12 | — | — | WO | disclosed |
| CN-106316965-A | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2017-01-11 | — | — | CN | disclosed |