Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 4/20 | 0.60 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.60 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.60 |
| ▸ | SYK | P43405 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 4/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.54 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.53 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.52 |
| ▸ | CDK2 | P24941 | 1/20 | 0.52 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.52 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.52 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 3/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18377040 | 1.00 | PIK3CG (0.60) | PIK3CGPIK3CAPIK3CBSYKUSP2 | |
| SCHEMBL29371938 | 0.90 | MAPK10 (0.55) | PIK3CGPIK3CAPIK3CBSYKCYP1A2 | |
| SCHEMBL18377036 | 0.90 | MAPK10 (0.55) | PIK3CGPIK3CAPIK3CBSYKCYP1A2 | |
| SCHEMBL29371294 | 0.90 | MAPK10 (0.60) | PIK3CGPIK3CAPIK3CBSYKMEN1 | |
| SCHEMBL18376750 | 0.90 | MAPK10 (0.60) | PIK3CGPIK3CAPIK3CBSYKMEN1 | |
| SCHEMBL18377073 | 0.90 | KDR (0.52) | PIK3CGPIK3CAPIK3CBSYKUSP2 | |
| SCHEMBL29370836 | 0.90 | KDR (0.52) | PIK3CGPIK3CAPIK3CBSYKUSP2 | |
| SCHEMBL29372255 | 0.87 | RIPK2 (0.69) | PIK3CGPIK3CAPIK3CBCLK4MAPK10 | |
| SCHEMBL18377044 | 0.87 | RIPK2 (0.69) | PIK3CGPIK3CAPIK3CBCLK4MAPK10 | |
| SCHEMBL29371800 | 0.85 | PTK2 (0.58) | CLK4MAPK10KDRPTK2JUN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113999180-A | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2022-02-01 | — | — | CN | claimed |
| CN-113999180-B | Quinazoline compound, intermediate, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2024-03-26 | — | — | CN | disclosed |
| CN-113999180-A | Quinazoline compound, intermediate thereof, preparation method, pharmaceutical composition and application | 上海医药集团股份有限公司 | 2022-02-01 | — | — | CN | disclosed |