Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18377660 | 1.00 | KDM5A (0.31) | KDM5AMAP3K12 | |
| SCHEMBL18377725 | 0.87 | KDM5A (0.34) | KDM5A | |
| SCHEMBL19732432 | 0.87 | KDM5A (0.34) | KDM5A | |
| SCHEMBL18377919 | 0.81 | KDM5A (0.35) | KDM5A | |
| SCHEMBL18367601 | 0.81 | MAP3K12 (0.32) | MAP3K12 | |
| SCHEMBL19589444 | 0.81 | CYP2C19 (0.40) | MAP3K12 | |
| SCHEMBL18377699 | 0.78 | KDM5A (0.38) | KDM5AMAP3K12 | |
| SCHEMBL18377717 | 0.78 | KDM5A (0.30) | KDM5A | |
| SCHEMBL18377666 | 0.75 | KDM5A (0.32) | KDM5A | |
| SCHEMBL18377698 | 0.75 | KDM5A (0.32) | KDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170362201-A1 | COT MODULATORS AND METHODS OF USE THEREOF | GILEAD SCIENCES, INC. | 2017-12-21 | — | — | US | disclosed |
| US-9815818-B2 | Cot modulators and methods of use thereof | GILEAD SCIENCES, INC. (US) | 2017-11-14 | — | — | US | disclosed |
| US-20170008873-A1 | COT MODULATORS AND METHODS OF USE THEREOF | GILEAD SCIENCES, INC. | 2017-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170362201-A1 | COT MODULATORS AND METHODS OF USE THEREOF | BRDT, THRB, HCCS | KDM5A 1081/4885MAP3K12 2435/4885 |
| US-20170008873-A1 | COT MODULATORS AND METHODS OF USE THEREOF | BRDT, THRB, HCCS | KDM5A 1081/4885MAP3K12 2435/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.