Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 13/20 | 0.42 |
| ▸ | ABL1 | P00519 | 12/20 | 0.42 |
| ▸ | EGFR | P00533 | 11/20 | 0.42 |
| ▸ | HCK | P08631 | 10/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.42 |
| ▸ | KDR | P35968 | 7/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.42 |
| ▸ | MTOR | P42345 | 7/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.42 |
| ▸ | EPHB4 | P54760 | 7/20 | 0.42 |
| ▸ | PRKDC | P78527 | 7/20 | 0.42 |
| ▸ | PI4KB | Q9UBF8 | 7/20 | 0.42 |
| ▸ | ITK | Q08881 | 1/20 | 0.41 |
| ▸ | PTK6 | Q13882 | 5/20 | 0.41 |
| ▸ | FYN | P06241 | 3/20 | 0.41 |
| ▸ | LCK | P06239 | 2/20 | 0.41 |
| ▸ | YES1 | P07947 | 2/20 | 0.41 |
| ▸ | LYN | P07948 | 2/20 | 0.41 |
| ▸ | FGR | P09769 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14706430 | 0.94 | EGFR (0.42) | SRCABL1EGFRHCKPIK3CD | |
| SCHEMBL14706422 | 0.93 | RIPK1 (0.41) | SRCABL1EGFRHCKPIK3CD | |
| SCHEMBL14706389 | 0.92 | SRC (0.41) | SRCABL1EGFRHCKPIK3CD | |
| SCHEMBL15087012 | 0.91 | EGFR (0.47) | SRCABL1EGFRHCKPIK3CD | |
| SCHEMBL14693537 | 0.90 | BTK (0.45) | SRCABL1EGFRHCKPIK3CD | |
| SCHEMBL14693540 | 0.90 | BTK (0.45) | SRCABL1EGFRHCKPIK3CD | |
| SCHEMBL14706390 | 0.90 | EGFR (0.44) | SRCABL1EGFRHCKPIK3CD | |
| SCHEMBL15086973 | 0.89 | FGFR1 (0.42) | SRCABL1EGFRHCKPIK3CD | |
| SCHEMBL14693485 | 0.88 | BTK (0.45) | SRCABL1EGFRHCKPIK3CD | |
| SCHEMBL14693483 | 0.88 | BTK (0.45) | SRCABL1EGFRHCKPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9546172-B2 | Pyrazolo[3,4-d]pyrimidine and pyrazolo[2,3-d]pyrimidine compounds as kinase inhibitors | PHARMACYCLICS LLC (US) | 2017-01-17 | — | — | US | disclosed |
| US-9546172-B2 | Pyrazolo[3,4-d]pyrimidine and pyrazolo[2,3-d]pyrimidine compounds as kinase inhibitors | PHARMACYCLICS LLC (US) | 2017-01-17 | — | — | US | disclosed |