Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 4/20 | 0.58 |
| ▸ | JAK2 | O60674 | 7/20 | 0.37 |
| ▸ | JAK3 | P52333 | 6/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.32 |
| ▸ | TCF7L2 | Q9NQB0 | 2/20 | 0.32 |
| ▸ | UBE2M | P61081 | 1/20 | 0.32 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL183846 | 1.00 | CHEK2 (0.58) | CHEK2JAK2JAK3FFAR4HIF1A | |
| SCHEMBL184160 | 0.89 | CHEK2 (0.63) | CHEK2JAK2JAK3MAPTUBE2M | |
| SCHEMBL184161 | 0.89 | CHEK2 (0.63) | CHEK2JAK2JAK3MAPTUBE2M | |
| SCHEMBL1622069 | 0.87 | CHEK2 (0.51) | CHEK2JAK2JAK3FFAR4KDM4E | |
| SCHEMBL2733679 | 0.86 | CHEK2 (0.57) | CHEK2JAK2JAK3KDM4EMAPT | |
| SCHEMBL5506872 | 0.86 | CHEK2 (0.68) | CHEK2JAK2JAK3MAPTMEN1 | |
| SCHEMBL4015698 | 0.86 | CHEK2 (0.68) | CHEK2JAK2JAK3MAPTMEN1 | |
| SCHEMBL1624102 | 0.84 | CHEK2 (0.48) | CHEK2KDM4EMAPTMEN1ALDH1A1 | |
| SCHEMBL1623249 | 0.84 | CHEK2 (0.62) | CHEK2JAK2JAK3HIF1AMAPT | |
| Hydrochloric Acid SCHEMBL1624150 | 0.83 | CHEK2 (0.47) | CHEK2KDM4EMAPTMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957482-B1 | QUINAZOLINES USEFUL AS MODULATORS OF VOLTAGE GATED ION CHANNELS | VERTEX PHARMA (US) | 2012-01-04 | — | — | EP | disclosed |